CMC Medical CMC-Medical VELLORE Solved Paper-2015

  • question_answer
    The conversion of primary amide to a primary amine containing one carbon atom less. The name of the reaction is

    A)  Hofmann bromamide reaction

    B)  Claisen reaction

    C)  Cannizaro reaction

    D)  Riemer-Tiemann reaction

    E)  None of the above

    Correct Answer: A

    Solution :

                    The conversion is done by Hofmann bromamide reaction or Hofmann degradation of amides. The original amide on heating with a mixture of\[B{{r}_{2}}\]in the presence of NaOH or KOH to give amine. \[C{{H}_{3}}CON{{H}_{2}}+B{{r}_{2}}+4NaOH\xrightarrow{\Delta }\]                \[C{{H}_{3}}N{{H}_{2}}+2NaBr+N{{a}_{2}}C{{O}_{3}}+2{{H}_{2}}O\]


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