Manipal Medical Manipal Medical Solved Paper-2012

  • question_answer
    Which antibiotic inhibits interaction between \[tRNA\]and\[mRNA\]during bacterial protein synthesis?

    A)  Neomycin

    B)  Streptomycin

    C)  Tetracycline

    D)  Erythromycin

    Correct Answer: C

    Solution :

     Tetracycline interferes with the attachment of \[tRNA\]carrying the amino acid to the mRNA-ribosome  complex preventing the addition of amino acids to the growing polypeptide chain. Streptomycin interferes with the initial steps of protein synthesis by changing the shape of 30 S proton of 70S prokaryotic ribosome. Erythromycin reacts with 50 S portion of the 70 S prokaryotic ribosome.


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