Answer:
Recombinant DNA vaccines are made up of a
small circular DNA (plasmid) that has very tiny piece of pathogen DNA
incorporated in it to produce one or two specific proteins of the pathogen.
This recombinant DNA is introduced in to
the bacteria or yeast cells, where it can use cell's machinery to produce
polypeptides of pathogen. These are used as vaccine to trigger arrange of
immune responses.
Vaccines produced by using this
approach allow large scale production, e.g.,
(i) Hepatitis-B vaccine produced
from yeast.
(ii) Bird flu DNA vaccine.
Advantages
(i) Recombinant DNA vaccines are
advantageous over killed or attenuated vaccines since ,they does not get
virulent or mutated again as it is seen in case of attenuated vaccines.
(ii) Secondly these are highly pure,
specific and elicits strong immune response.
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