Synthesis of DNA always takes place in 5' 3'direction.
In a double stranded DNA both strands are anti parallel and complementary. During
DNA synthesis as both strands act as templates, only one strand, i.e., 3' 5' can
synthesis complementary strand in 5' 3'direction.
The other strand, i.e., 5'' 3' has to be synthesized
in small stretches in opposite direction as replication fork moves to right.
That is why DNA synthesis is discontinuous on one of the parental strands of
DNA. These small stretches called Okazaki fragments are joined together by DNA
ligase enzyme that closes the nicks.
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