Answer:
Due to point mutation in p-globin chain of
haemoglobin molecule, glutamic acid (Glu) is replaced by valine (Val) at the
sixth position. Under stress condition erythrocytes lose their circular shape
and become sickle-shaped, Asa result, the cells cannot pass through narrow
capillaries. Blood capillaries are clogged and thus affect blood supply to
different organs.
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