12th Class Biology Molecular basis of inheritance

  • question_answer 49)   Based on your understanding of genetic code, explain the formation of any abnormal haemoglobin molecule. What are the known consequences of such a change?


                      Due to point mutation in p-globin chain of haemoglobin molecule, glutamic acid (Glu) is replaced by valine (Val) at the sixth position. Under stress condition erythrocytes lose their circular shape and become sickle-shaped, Asa result, the cells cannot pass through narrow capillaries. Blood capillaries are clogged and thus affect blood supply to different organs.

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