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question_answer1)
The chemical nature of a gene is
A)
protein done
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B)
acid done
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C)
base done
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D)
none of these done
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question_answer2)
Number of base pairs in DMA helix around the octamer histone molecule is
A)
140 - 200 bp done
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B)
100 -150 bp done
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C)
40 - 67 bp done
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D)
200 - 260 bp done
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question_answer3)
International Human Genome Project began in
A)
1990 done
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B)
1996 done
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C)
2000 done
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D)
2001 done
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question_answer4)
Chargaffs rules of base pairing states that
A)
The ratio of purines to pyrimidines is roughly equal in all tested organisms. done
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B)
The ratio of A to T is roughly equal in all tested organisms. done
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C)
The ratio of A + T and G + C is roughly equal in all tested organisms. done
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D)
a and b done
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question_answer5)
Watson and Crick's model allowed them to visualize
A)
The molecular bonds of DNA done
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B)
How the purines and pyrimidines fit together in a double helix. done
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C)
That the two strands of the DNA double helix were antiparallel. done
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D)
All of the above done
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question_answer6)
The primary function of DNA polymerase is to
A)
Add nucleotides to the growing daughter strand. done
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B)
Seal nicks along the sugar-phosphate backbone of the daughter strand. done
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C)
Unwind the parent DNA double helix. done
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D)
Prevent reassociation of the denatured parent DNA strands. done
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question_answer7)
Proofreading and repair occur
A)
At anytime during or after synthesis of DNA done
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B)
Only before DNA methylation occurs. done
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C)
Only in the presence of DNA polymerase. done
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D)
Only in the presence of an excision repair mechanism. done
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question_answer8)
DNA replication is an ______ process and _________ energy.
A)
Exergonic; does not require done
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B)
Endothermic; does require done
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C)
Endergonic; does require done
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D)
Endodontic; does not require done
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question_answer9)
Which of the following would not be found in a DNA molecule?
A)
Purines done
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B)
Sugars done
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C)
Phosphates done
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D)
Sulfur done
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question_answer10)
Which statement about complementary base pairing is not true?
A)
It plays a role in DNA replication done
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B)
In DNA, T pairs with A done
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C)
Purines pair with purines, and pyrimidines pair with pyrimidines. done
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D)
In DNA, C pairs with G. done
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question_answer11)
The leading strand and lagging strand in DNA replication differ in that only on the lagging strand
A)
DNA is replicated as short fragments. done
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B)
RNA primer is present, done
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C)
Replication proceeds in the 5' to 3' direction done
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D)
DNA ligase is not needed. done
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question_answer12)
How many adenylate residues are added at 3' end during the processing of hnRNA in eukaryotes?
A)
50-100 done
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B)
100-150 done
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C)
600-700 done
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D)
200-300 done
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question_answer13)
Which of the following model organisms has been sequenced?
A)
Drosophila done
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B)
Bacteria done
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C)
Yeast done
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D)
All done
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question_answer14)
nu body of nucleosome consists of
A)
\[{{H}_{1}}\]and \[{{H}_{2}}A\] done
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B)
(b \[{{H}_{2}}A\] and \[{{H}_{2}}B\] done
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C)
\[{{H}_{3}}\] and \[{{H}_{4}}\] done
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D)
Both [b] & [c] done
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question_answer15)
Which one of the following is used as marker chromosome?
A)
Monocentric chr. done
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B)
SAT-chromosome done
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C)
Idiosome done
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D)
chromosome done
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question_answer16)
HOP methodology which includes identification of all the genes that expressed as RNA is referred as
A)
RFLP done
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B)
ESTs done
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C)
VNTR done
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D)
RAPD's done
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question_answer17)
The last human chromosome which sequence was completed in May 2006 is
A)
Chromosome 22 done
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B)
Chromosome 1 done
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C)
Chromosome 1 done
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D)
Chromosome X and Y done
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question_answer18)
Separation of DNA fragments into bands by electrophoresis is done on
A)
Agarose gel done
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B)
Polyacrylamide gel done
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C)
Arabic gum done
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D)
Both [a] and [b] done
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question_answer19)
Enzyme utilised for the synthesis of RNA copolymers and homopolymers during deciphering of genetic code is-
A)
DNA dependent RNA polymerase done
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B)
RNA dependent DNA polymerase done
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C)
DNA independent RNA polymerase done
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D)
DNA dependent DNA polymerase done
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question_answer20)
The entire genetic code consists of __ amino acids and __ codons.
A)
20, 20 done
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B)
20, 64 done
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C)
30, 60 done
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D)
30, 72 done
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question_answer21)
Which mode of information transfer usually does not occur?
A)
DNA to DNA done
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B)
DNA to RNA done
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C)
DNA to protein done
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D)
All occur in a working cell done
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question_answer22)
Which of the following is not the characteristic feature of genetic code
A)
Triplet in nature done
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B)
Mostly universal done
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C)
Ambiguous done
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D)
Degeneracy done
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question_answer23)
Which one of the following is a wrong statement regarding mutations?
A)
Deletion and insertion of base pairs cause frame-shift mutations done
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B)
Cancer cells commonly show chromosomal aberrations done
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C)
UV and Gamma rays are mutagens done
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D)
Change, in a single base pair of DNA does not cause mutation done
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question_answer24)
What is it that forms the basis of DNA Fingerprinting?
A)
The relative proportions of purines and pyrimidines in DNA done
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B)
The relative difference in the DNA occurrence in blood, skin and saliva done
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C)
The relative amount of DNA in the ridges and grooves of the fingerprints. done
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D)
Satellite DNA occurring as highly repeated short DNA segments done
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question_answer25)
Crick, one of the discoverer of DNA double helical structure, was the man of
A)
Physics done
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B)
Chemistry done
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C)
Zoology done
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D)
Botany done
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question_answer26)
The number of codons that code different amino acids is -
A)
16 done
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B)
31 done
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C)
61 done
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D)
64 done
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question_answer27)
Out of 64 codons, the number of codons with GGG is
A)
1 done
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B)
2 done
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C)
4 done
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D)
6 done
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question_answer28)
If one strand of DNA has the nitrogenous base sequence at ATCTG, what would be the complementary RNA strand sequence
A)
TTAGU done
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B)
UAGAC done
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C)
AACTG done
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D)
ATCGU done
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question_answer29)
Removal of introns and joining of exons in a defined order during transcription is called:
A)
Looping done
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B)
Inducing done
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C)
Slicing done
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D)
Splicing done
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question_answer30)
The diagram shows an important concept in the genetic implication of DNA. Fill in the blanks A to C.
A)
A-translation, B-transcription, C-Erwin Chargaff done
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B)
A-transcription, B-translation, C-Francis Crick done
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C)
A-translation, B-extension, C-Rosalind Franklin done
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D)
A-transcription, B-replication, C-James Watson done
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question_answer31)
Nucleosome consist of repeated unit of structure in nucleus called
A)
Chromatin done
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B)
Chromosome done
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C)
Histone octamer done
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D)
Nucleotide done
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question_answer32)
Which of the following pairs is incorrectly matched?
A)
Purines - Adenine and Guanine done
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B)
Pyrimidines - Cytosine and Uracil done
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C)
Nucleosides - Adenosine and Thymidine done
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D)
DNA - Basic biomolecule done
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question_answer33)
In nucleotide molecule, nitrogenous base is linked to pentose sugar by A linkage and the pentose sugar is linked to phosphate by B linkage. Identify A and B.
A)
B)
C)
D)
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question_answer34)
Semi - conservative nature of DNA experiment given by
A)
Marshey and Chase done
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B)
Alfred Hershey and Martha Chase done
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C)
Matthew Meselson and Franklin Stahl done
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D)
MacLoad and Maclyn MacCarty done
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question_answer35)
If the DNA of a vims is labelled with \[^{32}P\] and the protein of the virus is labelled \[^{35}S\], after transduction which molecule (s) would be present inside the bacterial cells?
A)
\[^{32}P\] only done
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B)
\[^{35}S\] only done
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C)
Both "S and32? done
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D)
(d Neither molecule would be present inside the cell done
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question_answer36)
Which of the following statement is incorrect?
A)
Both DNA and RNA are able to mutate. done
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B)
Griffith's transforming principle also explained the stability of genetic material. done
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C)
DNA chemically is less reactive and structurally more stable. done
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D)
RNA is passed from vims to bacteria. done
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question_answer37)
Larger submit ofribosome contains:
A)
Gyrase done
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B)
Peptidyl transferal done
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C)
Topoisomerase done
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D)
RNA - polymerase done
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question_answer38)
Okazaki fragments during DNA replication:
A)
Polymerise in \[5'\to 3'\] direction and explain \[3'\to 5'\]DNA replication done
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B)
Prove semiconservative DNA replication done
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C)
Polymerase in \[3'\to 5'\] direction and replication fork done
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D)
Cause transcription done
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question_answer39)
The discontinuously synthesized fragments are joined by the enzyme
A)
DNA ligase done
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B)
DNA polymerase done
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C)
Helicase done
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D)
Lyase done
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question_answer40)
DNA unwinding is done by
A)
Ligase done
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B)
Helicase done
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C)
Topoisomerase done
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D)
Hexonuclease done
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question_answer41)
Coding sequence which appear in mature RNA is
A)
Exon done
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B)
Intron done
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C)
Cistron done
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D)
Splicing done
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question_answer42)
Capping is a process in which
A)
Adenylate is added at 5 end done
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B)
Methyl guanosine triphosphate is added at 5 end done
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C)
Adenylate is added at 3 end done
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D)
Methyl guanosine triphosphate is added at 3 end done
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question_answer43)
Given diagram represents the components of a transcription unit. Select the correct answer regarding it. |
|
A)
B)
C)
D)
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question_answer44)
Select the incorrectly matched pair
A)
Initiation Codons - AUG, GUG done
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B)
Stop codons - UAA, UAG, UGA done
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C)
Methionine - AUG done
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D)
Anticodons - mRNA done
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question_answer45)
Reverse transcriptase:
A)
Transcribes viral RNA to cDNA done
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B)
Polymerises host DNA done
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C)
Translates host DNA done
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D)
Disintegrates host DNA done
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question_answer46)
Match the column -1 with column - II
Column - I (Process) | Column - II (Enzyme involved) |
A. Termination | DNA polymerase |
B. Translation | Peptidyl transferase |
C. Transcription | Reverse transcription |
D. Replication | RNA polymerase |
A)
A - 2 B - 4 C - 1 D - 3 E - 5 done
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B)
A - 4 B - 2 C - 1 D - 3 E - 5 done
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C)
A - 3 B - 2 C - 5 D - 4 E - 1 done
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D)
A - 4 B - 3 C - 5 D - 2 E - 1 done
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question_answer47)
Frame shift mutations are caused by
A)
Inversion and translocation done
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B)
Deletion and insertion done
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C)
Deletion and transversion done
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D)
Insertion and inversion done
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question_answer48)
Gene capable of moving from the chromosome to another is:
A)
Cosmid done
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B)
Transposon done
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C)
Exonic gene done
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D)
Mutated gene done
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question_answer49)
The process of translation is:
A)
Ribosome synthesis done
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B)
RNA synthesis done
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C)
DNA synthesis done
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D)
Protein synthesis done
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question_answer50)
Polymorphism is
A)
Variation at cellular level done
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B)
Variation at chromosomal level done
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C)
Variation at genetic level done
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D)
None of the above done
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question_answer51)
The sequence of a structural gene in lac operon is
A)
lac a, lac y and lac z done
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B)
lac a, lac z and lac y done
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C)
lac y, lac z and lac a done
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D)
lac z, lac y and lac a done
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question_answer52)
Which of the following in not produced by E. coli in the lac operon?
A)
\[\beta \] galactosidase done
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B)
Thiogalactoside transacetylase done
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C)
Lactose dehydrogenase done
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D)
Lactose permease done
clear
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question_answer53)
The inducer of lac operon is
A)
Permease done
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B)
Lactose done
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C)
Galactose done
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D)
Transacetylase done
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question_answer54)
The commonly used hosts in HOP were
A)
Bacteria and yeast done
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B)
Bacteria and fungi done
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C)
Protozoa and bacteria done
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D)
Plants and fungi done
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question_answer55)
DNA fingerprinting technique was developed by:
A)
Boysen and Jensen done
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B)
Schleiden and Schwann done
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C)
Jeffreys et al done
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D)
Edwards and Steptoe done
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question_answer56)
Which of the following correctly describes chromatin?
A)
The complex of DNA and protein from which chromosomes are composed. done
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B)
the total genetic content of a cell. done
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C)
The proteins that give structural support to a done
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D)
Unpacked DNA done
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question_answer57)
Match the column and find out the correct combination: |
|
Gene |
Product |
Function of the product |
I. |
z-gene |
\[\beta \]-galactosidase |
Hydrolysis lactose |
II. |
y-gene |
Transacetylase |
Uptake of lactose |
III. |
a-gene |
Permease protein |
Function not known |
IV. |
Inhibitor gene |
Repressor protein |
Switch off operator gene |
|
A)
II and III done
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B)
I and III done
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C)
I, III, IV done
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D)
I and IV done
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question_answer58)
Select the incorrect statement about lac operon when lactose is present in the medium.
A)
Gene a gets transcribed into mRNA which produces \[\beta \]-galactosidepermease done
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B)
Lactose inactivates represser protein done
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C)
RNA polymerase transcribe z-gene, y-gene and a-gene done
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D)
Allolactose is the inducer of lac operon done
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question_answer59)
Consider the following statement w.r.t. human genome project and select the wrong choice.
A)
Scientists have identified about 1.4 million locations where SNPs occur. done
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B)
The human genome contains 3164.7 billion nucleotide base. done
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C)
The total number of genes is estimated at 30,000. done
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D)
Less than 2 percent of the genome codes for proteins. done
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question_answer60)
In E. coli, rhofactor is required for:
A)
Initiation of transcription at specific site done
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B)
Initiation of transcription at many site done
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C)
Termination of transcription at specific site done
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D)
Termination of transcription at many sites done
clear
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