question_answer 1)
DNA polymerisation rate of DNA polymerase is:
A)
\[3.9\times {{10}^{7}}bp\] done
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B)
2000\[bp/s\] done
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C)
\[4.6\times {{10}^{6}}bp\] done
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D)
5000\[bp/s\] done
clear
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question_answer 2)
If a nucleotide lacking a hydroxyl group at the 3' end is added to a PCR, what would be the outcome?
A)
No additional nucleotides would be added to a growing strand containing that nucleotide. done
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B)
Strand elongation would proceed as normal. done
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C)
Nucleotides would only be added at the 5' end. done
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D)
T. aquaticus DNA polymerase would be denatured. done
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question_answer 3)
Which of the following would you expect to find in an inducible system
A)
A repressor protein, which is bound to DNA in absence of any other factor. done
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B)
A repressor protein, which is bound to DNA in the presence of a co-repressor. done
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C)
An activator protein, which is bound to D in absence of any other factor. done
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D)
An activator protein, which is bound to DNA only in the absence of an inhibitor. done
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question_answer 4)
Nonsense codon takes part in:
A)
Terminating message of gene controlled protein synthesis. done
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B)
Formation of unspecified amino acids. done
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C)
Conversion of sense DNA into non-sense one. done
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D)
Releasing t RNA from polypeptide chain. done
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question_answer 5)
Information flow or central dogma of modem biology is:
A)
RNA \[\to \] Proteins \[\to \] DNA. done
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B)
DNA \[\to \] RNA \[\to \] Proteins. done
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C)
RNA \[\to \] DNA \[\to \] Proteins. done
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D)
DNA \[\to \] RNA \[\to \] Proteins. done
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question_answer 6)
AUG initiation codon occurs over:
A)
3'end of mRNA done
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B)
5'end of m RNA done
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C)
Short arm of t RNA done
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D)
long arm of t RNA done
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question_answer 7)
What effect would you expect if gene expression of the lac operon was completely repressed?
A)
The cell would be more efficient without wasting' the energy required for the low level of Lac Z, Lac Y, and Lac A gene expression. done
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B)
Allolactose would accumulate within the cell and become toxic. done
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C)
Lactose would not be converted into the inducer and the operon could not be induced. done
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D)
All of the above done
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question_answer 8)
Identify the correct labelling of A, B, C, D & E.
A)
A-Hydrogen bonds, -B-Pyrimidine, C-Hexose (deoxyribose) sugar, D-5' end, E-Purine base done
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B)
A-Hydrogen bonds, B-Purine base, C-Hexose (deoxyribose) sugar,-D-5' end, E-Pyrimidine done
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C)
A-Hydrogen bonds, B-Pyrimidine, C-Pentose (deoxyribose) sugar, D-5' end, E-Purine base done
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D)
A-Hydrogen bonds, B-Purine base, C-Pentose (deoxyribose) sugar, D- 5' end, E- Pyrimidine done
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question_answer 9)
Given diagram represents the schematic structure of a transcription unit with some parts labeled as A B C and D. Select the option which shows its correct labeling.
A)
B)
C)
D)
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question_answer 10)
Which enzymes will be produced in a cell in which there is a nonsense mutation in the lac Y gene?
A)
Lactose Permease done
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B)
Transacetylase done
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C)
Lactose permease and transcetylase done
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D)
\[\beta \]-galactosidase done
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question_answer 11)
SNP which is pronounced as "snips" stands for:
A)
Small Nuclear Protein done
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B)
Single Nucleotide Particle done
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C)
Single Nucleotide Polymorphism done
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D)
Small Nicking Points done
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question_answer 12)
The key finding of the Hershey and Chase experiments on the mechanism of viral replication was that:
A)
Protein, not DNA, is the hereditary material. done
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B)
DNA, not protein, is the hereditary material. done
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C)
Protein and DNA play an equal role in determining inheritance. done
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D)
Neither protein nor DNA play a role in determining inheritance. done
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question_answer 13)
Which of the following is/are correct matching(s)?
Codon Amino acid (i) \[^{5'}AU{{G}^{3'}}\] Serine (ii) \[^{5'}AU{{C}^{3'}}\] Tyrosine (iii) \[^{5'}AU{{G}^{3'}}\] Methionine (iv) \[^{5'}GU{{G}^{3'}}\] Valine
A)
(i) and (iii) done
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B)
All of these done
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C)
(ii), (iii) and (iv) done
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D)
(i),(ii) and (iii) done
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question_answer 14)
Select the two correct statements out of the four (i - iv) given below about lac operon.
(i) Glucose or galactose may bind with the repressor and inactivate it. (ii) In the absence of lactose the repressor binds with the operator region. (iii) The z-gene codes for permease. (iv) This was elucidated by Francois Jacob and Jacque Monod.
A)
(ii) and (iii) done
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B)
(i) and (iii) done
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C)
(ii) and (iv) done
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D)
(i) and (ii) done
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question_answer 15)
Match column-I with column-II and select the correct answer using the codes given below.
Column-I Column-II A. Operator site I. Binding site for RNA polymerase B. Promoter site II. Binding site for repressor molecule C. Structural gene III. Codes for enzyme protein D. Regulator gene IV. Codes for repressor molecules
A)
A-II; B-I; C-III; D-IV done
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B)
A-II; B-I; C-IV; D-II I done
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C)
A-IV; B-III; C-I; D-II done
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D)
A-II; B-III; C-I; D-IV done
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question_answer 16)
A bacterium grown over medium having radioactive \[^{35}S\] incorporates radioactivity in:
A)
Carbohydrates done
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B)
Proteins done
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C)
DNA done
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D)
RNA done
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question_answer 17)
If a double stranded DNA has 20% of cytosine, what will be the percentage of adenine in it?
A)
20% done
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B)
40% done
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C)
30% done
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D)
60% done
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question_answer 18)
Chargaff's rules of base pairing states that:
A)
The ratio of purines to pyrimidines is roughly equal in all tested organisms. done
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B)
The ratio of A to T is roughly equal in all tested organisms. done
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C)
The ratio of A + T and G + C is roughly equal in all tested organisms. done
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D)
Both [a] and [b] done
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question_answer 19)
Thirty percent of the bases in a sample of DNA extracted from eukaryotic cells is adenine. What percentage of cytosine is present in this DNA?
A)
10% done
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B)
20% done
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C)
30% done
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D)
40% done
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question_answer 20)
Lac operon is:
A)
Arabinose operon done
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B)
Repressible operon done
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C)
Inducible operon done
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D)
Overlapping genes done
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question_answer 21)
DNA packaging is the way DNA is folded into chromosomes that affects gene expression by:
A)
Controlling access to DNA. done
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B)
Positioning related genes near each other. done
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C)
Protecting DNA from mutations. done
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D)
Enhancing recombination of genes. done
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question_answer 22)
The most common way of gene expression is regulated in both prokaryotes and eukaryotes is through the:
A)
Control of mRNA translation. done
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B)
Breakdown of proteins formed by translation. done
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C)
Prevention of DNA uncoiling prior to transcription. done
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D)
Control of gene transcription. done
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question_answer 23)
Lactose operon produces enzymes:
A)
\[\beta \]-galactosidase, permease and glycogen synthetase. done
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B)
\[\beta \]-galactosidase, permease and transacetylase. done
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C)
Permease, glycogen synthetase and transacetylase. done
clear
D)
\[\beta \]-galactosidase, permease and phosphoglucose isomerase. done
clear
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question_answer 24)
In negative operon:
A)
Co-repressor binds with repressor done
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B)
Co-repressor does not bind with repressor done
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C)
Co-repressor binds with inducer done
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D)
cAMP have negative effect on lac operon done
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question_answer 25)
Which of the following is the first thing that happens when a signal molecule acts on a target cell?
A)
A transcription factor acts on the DNA. done
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B)
The signal molecule binds to RNA. done
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C)
A new protein is made in the target cell. done
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D)
The signal molecule binds to a receptor. done
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question_answer 26)
Antibiotic inhibiting interaction between t RNA and mRNA during protein synthesis in bacteria is:
A)
Tetracycline done
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B)
Neomycin done
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C)
Erythromycin done
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D)
Streptomycin done
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question_answer 27)
Which of the following statement forms the basis of DNA fingerprinting?
A)
The relative proportions of purines and pyrimidines in DNA. done
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B)
Satellite DNA occurring as highly repeated short DNA segments. done
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C)
The relative difference in the DNA occurrence in blood, skin and saliva. done
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D)
The relative amount of DNA in the ridges and grooves of the fingerprints. done
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question_answer 28)
Identify the statements pertaining to the regulatory genes (R), associated with the lac operon that are incorrect.
(i) mRNA is transcribed from the R gene whether lactose is present or not. (ii) mRNA is transcribed from the R gene only when the lactose is present. (iii) mRNA is transcribed from the R gene only when the lactose is not present. (iv) Lactose inhibits the translation or R gene mRNA.
A)
(i) and (ii) done
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B)
(ii) and (iii) done
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C)
(iii) and (iv) done
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D)
(ii), (iii) and (iv) done
clear
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question_answer 29)
Which one of the following group of codons is called as degenerate codons?
A)
UAA, UAG and UGA done
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B)
GUA, GUG, GCA, GCG and GAA done
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C)
UUC, UUG, CCU, CAA and CUG done
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D)
UUA, UUG, CUU, CUC, CUA and CUG done
clear
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question_answer 30)
Which of the following characters is not associated with a leading strand?
A)
Its replication proceeds away from the fork. done
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B)
Its replication takes place in continuous manner. done
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C)
Its replication takes place in along 3'-5' direction of template strand. done
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D)
All of the above. done
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question_answer 31)
Number of ammo acids in a polypeptide chain is 150. The number of mRNA bases required is: given species:
A)
150 done
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B)
450 done
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C)
100 done
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D)
50 done
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question_answer 32)
In a mutational event, when adenine is replaced by guanine, it is a case of:
A)
Frame shift mutation done
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B)
Transcription done
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C)
Transition done
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D)
Transversion done
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question_answer 33)
The following ratio is generally constant for a given species:
A)
\[\frac{A+G}{C+T}\] done
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B)
\[\frac{T+C}{G+A}\] done
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C)
\[\frac{A+T}{G+C}\] done
clear
D)
\[\frac{A+C}{T+G}\] done
clear
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question_answer 34)
In an eukaryote, a repressor protein may block gene expression by binding to a DNA site called :
A)
Operon done
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B)
Histone done
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C)
Enhancer done
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D)
Promoter done
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question_answer 35)
The given figure shows lac operon model and its functioning. Select the option which correctly labels A, B, X, Y and Z marked in the figure and also identify the label (L) which is primarily responsible for the hydrolysis of the disaccharide, lactose, into galactose & glucose.
A)
B)
C)
D)
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question_answer 36)
Identify the labels A, B, C and D in the given structure of t RNA and select the correct option.
A)
B)
C)
D)
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question_answer 37)
Find out the correct statement.
A)
Uracil is present in RNA at the place of thymine. done
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B)
The complex of DNA and protein in chromosome is called chromatin. done
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C)
Heterochromatin is the most highly condensed form of chromatin. done
clear
D)
The process involved in the RNA formation on the DNA template is called replication. done
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question_answer 38)
DNA fingerprinting using Variable Number Tandem Repeats (VNTRs) is based on the observation that:
A)
Every individual has unique alleles at each VNTR locus. done
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B)
The DNA of VNTR loci is more stable than that of loci which code for proteins. done
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C)
VNTR sequences show little variability. done
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D)
VNTR loci are highly polymorphic. done
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question_answer 39)
Satellite DNA:
A)
Is classified in many categories such as micro-satellites, mini satellites, etc. on the basis of base composition length of segments and number of repetitive units. done
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B)
Normally does not code for any protein. done
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C)
Shows polymorphism. done
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D)
All of the above done
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question_answer 40)
Chargaff's rule is applicable to:
A)
Single stranded RNA done
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B)
Single stranded DNA and RNA done
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C)
Single stranded DNA done
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D)
Double stranded DNA done
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question_answer 41)
Match the enzymes given in column-I with its function given in column-II and select the correct option.
Column-I Column-II A. \[\beta \]- galactosidase I. Joining of DNA fragments B. Permease II. Peptide bond formation C. Ligase III. Hydrolysis of lactose D Ribozyme IV. Increase permeability of galactosidase
A)
A-II; B-I; C-IV; D-III done
clear
B)
A-III; B-IV; C-I; D-II done
clear
C)
A-II; B-IV; C-I; D-III done
clear
D)
A-I; B-II; C-IV; D-III done
clear
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question_answer 42)
Operon is a:
A)
Sequence of three nitrogen bases determining a single amino acid. done
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B)
Set of closely placed genes regulating a metabolic pathway in prokaryotes. done
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C)
Segment of DNA specifying a polypeptide. done
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D)
Gene responsible for switching on and switching off other genes. done
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question_answer 43)
Genes that are involved in turning on or off the transcription of a set of structural genes are called:
A)
Operator genes done
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B)
Redundant genes done
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C)
Regulator genes done
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D)
Polymorphic genes done
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question_answer 44)
If the gene encoding the trp repressor is mutated such that it can no longer bind to tryptophan, will transcription of the trp operon occur?
A)
Yes, because the trp repressor can only bin the trp operon and block transcriptional initiation when it is bound to tryptophan. done
clear
B)
No, because this mutation does not affect the part of the repressor that can bind the operator. done
clear
C)
No, because the trp operon is repressed only when tryptophan levels are high. done
clear
D)
Yes, because the trp operon can allosterically regulate the enzymes needed to synthesise the amino acid tryptophan. done
clear
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question_answer 45)
Transcriptional regulation:
A)
Is highly efficient at completely preventing transcription. done
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B)
Allows the cell to only produce proteins that are needed at the time. done
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C)
Can be induced by a repressor protein. done
clear
D)
All of the above done
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question_answer 46)
Post-transcriptional regulation includes:
A)
Binding of repressor on silencer regions. done
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B)
Transport of messenger RNA into the cytoplasm. done
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C)
Decreasing messenger RNA stability in the cytoplasm. done
clear
D)
Both [b] and [c] done
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question_answer 47)
Mutations which alter nucleotide sequence within a gene are called:
A)
Frame shift mutations done
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B)
Base pair substitutions done
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C)
Both [a] and [b] done
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D)
None of the above done
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question_answer 48)
What would happen if a mutation occurred in the DNA such that the second codon of a polypeptide, UGC, was changed to a UAG?
A)
Nothing. The ribosome would skip that codon and translation would continue. done
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B)
Translation would continue, but the reading frame of the ribosome would be shifted. done
clear
C)
Translation would stop at the second codon and no functional protein would be made. done
clear
D)
Translation would continue, but the second amino acid in the protein would be different. done
clear
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question_answer 49)
Which statement is/are correct?
(i) Nucleosome contains basic protein. (ii) Tightly packed DNA of chromatin is called heterochromatin. (iii) Loosely packed DNA of chromatin is called euchromatin. (iv) \[{{H}_{2}}A,{{H}_{2}}B\] are linker proteins. (v) DNA is basic in nature.
A)
(i),(ii) and (iii), done
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B)
(i) and (ii) done
clear
C)
(i), (ii), (iii), (iv) and (v) done
clear
D)
(iv) and (v) done
clear
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question_answer 50)
Match column-I with column-II and select the correct answer using the codes given below.
Column-I Column-II A. Helicase I. Joining of nucleotides B. Gyrase II. Opening of DNA C. Primase III. Unwinding of DNA D. DNA polymerase IV. RNA priming
A)
A-II; B-I; C-III; D-IV done
clear
B)
A-II; B-I; C-IV; D-III done
clear
C)
A-IV; B-III; C-I; D-II done
clear
D)
A-II; B-III; C-IV; D-I done
clear
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question_answer 51)
Which of the following statements about the process of DNA replication is incorrect?
A)
Many different enzymes are needed for the process to function properly. done
clear
B)
Mistakes can be corrected at multiple steps in the process. done
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C)
Uncorrected mistakes introduce mutations into the DNA base sequence. done
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D)
Mistakes in the copying process are very common occurrences. done
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question_answer 52)
Experiments by Avery, McLeod, and McCarty supported DNA as the genetic material by showing that:
A)
Both protein and DNA samples provided the transforming factor. done
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B)
DNA was not complex enough to be the genetic material. done
clear
C)
Only samples with DNA provided activity. done
clear
D)
Even though DNA was molecularly simple, it provided adequate variation to act as the genetic material. done
clear
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question_answer 53)
Enzyme required for removing RNA primer during DNA replication is:
A)
Primase done
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B)
Ligase done
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C)
DNA polymerase I done
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D)
DNA polymerase III done
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question_answer 54)
Termination of polypeptide chain is brought about by:
A)
UUG done
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B)
UAA done
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C)
UUG done
clear
D)
UCG done
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question_answer 55)
Wobble hypothesis establishes:
A)
Peptide chain formation done
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B)
Initiation of peptide chain done
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C)
Termination of peptide chain done
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D)
Economy in t RNA molecules. done
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question_answer 56)
Regulated unit of genetic material is termed as:
A)
Operon done
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B)
Regulator gene done
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C)
Operator gene done
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D)
Okazaki segment done
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question_answer 57)
Identify the incorrect statement.
A)
In prokaryotes, the structural gene is polycistronic. done
clear
B)
In eukaryotes, structural genes have interrupted coding sequences. done
clear
C)
Eukaryotes have split gene arrangement. done
clear
D)
Intervening sequences appear in mature RNA. done
clear
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question_answer 58)
Which of the following statements about RNA polymerase are correct?
(i) RNA polymerase I transcribes rRNAs. (ii) RNA polymerase II transcribes snRNAs. (iii) RNA polymerase III transcribes hnRNA. (iv) RNA polymerase II transcribes hnRNAs.
A)
(i) and (ii) done
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B)
(i) and (iii) done
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C)
(ii) and (iii) done
clear
D)
(i) and (iv) done
clear
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question_answer 59)
The lagging daughter strand of DNA is synthesised in what appears to be the "wrong" direction. This synthesis is accomplished by:
A)
Ligating (connecting) short Okazaki fragments that are synthesised in short spurts in the "right" direction. done
clear
B)
Primase. done
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C)
Using multiple primers and DNA polymerase I. done
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D)
Both [a] and [b] done
clear
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question_answer 60)
Which of the following factor is required for the protein synthesis?
(i) Initiation codon (ii) GTP and ATP (iii) Peptidyl transferase (iv) tRNA (v) mRNA (vi) Amino acid activating enzyme (vii) rRNA Choose the correct combination.
A)
(i), (ii) and (iii) done
clear
B)
(iii), (iv) and (v) done
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C)
(v), (vi) and (vii) done
clear
D)
All of these done
clear
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question_answer 61)
During transcription, the DNA site at which RNA polymerase binds is called:
A)
Enhancer done
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B)
Promoter done
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C)
Regulator done
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D)
Receptor done
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question_answer 62)
If the nucleus of a frog egg is destroyed and replaced with the nucleus of an intestinal cell from a tadpole, the egg can develop into a normal tadpole. This demonstrates that:
A)
Intestinal cells are fully differentiated. done
clear
B)
There is little functional difference between an egg cell and an intestinal cell. done
clear
C)
An intestinal cell possesses a full set of genes. done
clear
D)
Intestinal cells are not differentiated. done
clear
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question_answer 63)
Which of the following does not play a role in the genetic regulation of tryptophan synthesis in the bacterium E. coli?
A)
RNA polymerase done
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B)
Homeotic gene done
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C)
Repressor protein done
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D)
Operator done
clear
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question_answer 64)
Which of the following is most abundant in human DNA?
A)
Regulatory genes done
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B)
Non-coding DNA done
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C)
Transposons done
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D)
Homeotic genes done
clear
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question_answer 65)
The regulation of tryptophan synthesis in E. coli is an example of affecting gene expression through:
A)
Translational control done
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B)
Transcriptional control done
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C)
Homeotic gene control done
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D)
Breaking down mRNA molecules done
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question_answer 66)
Isolation and purification of specific DNA segment from a living organism was achieved by:
A)
Nirenberg done
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B)
Lederberg done
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C)
Zacharis done
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D)
Watson & Crick done
clear
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question_answer 67)
Hershey and Chase used radioactive \[^{35}S\] and \[^{32}P\]in experiments to provide evidence that DNA was the genetic material. These experiments pointed to DNA because:
A)
Progeny viruses retained \[^{32}P\] but not\[^{35}S\]. done
clear
B)
Retention of \[^{32}P\] in progeny viruses indicated that DNA was passed on. done
clear
C)
Loss of \[^{35}S\] in progeny viruses indicated that proteins were not passed. done
clear
D)
All of the above done
clear
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question_answer 68)
Histones are rich in:
A)
Alanine and glycine done
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B)
Lysine and arginine done
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C)
Histidine and serine done
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D)
Cysteine and tyrosine done
clear
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question_answer 69)
Which of the following mechanisms of gene regulation operates after mRNA transcription but before translation of mRNA into protein?
A)
mRNA splicing done
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B)
DNA packing done
clear
C)
Repressors and activators done
clear
D)
Protein degradation done
clear
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question_answer 70)
The process of the elongation in transcription requires:
A)
\[C{{a}^{++}}\,or\,M{{n}^{++}}\] done
clear
B)
\[N{{a}^{+}}\,or\,C{{l}^{-}}\] done
clear
C)
\[N{{a}^{+}}\,or\,{{K}^{+}}\] done
clear
D)
\[M{{n}^{++}}\,or\,M{{g}^{+2}}\] done
clear
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question_answer 71)
DNA replication is:
A)
Conservative and discontinuous. done
clear
B)
Semi-conservative and semi-discontinuous. done
clear
C)
Semi-conservative and discontinuous; done
clear
D)
conservative done
clear
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question_answer 72)
DNA binding proteins:
A)
Have distinct three-dimensional structures that allow them to bind to the DNA. done
clear
B)
Are transcription factors. done
clear
C)
Inhibit the loss of ends from the chromosome and help DNA condense in the nucleus. done
clear
D)
All of the above done
clear
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question_answer 73)
A short sequence of bases on one strand of DNA is AGTCTACCGATAGT. If this sequence serves as a template for the formation of a new strand of DNA, what will be the corresponding base sequence in the new strand?
A)
AGTCTACCGATAGT done
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B)
TCAGATGGCTATCA done
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C)
TGATAGCCATCTGA done
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D)
GACATCGATTCGAT done
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question_answer 74)
DNA replication is semi-conservative as:
A)
Only non-parent strand acts as template. done
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B)
Both strands of new molecule are synthesized de novo. done
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C)
One of the strand in each new molecule is parental and the other is new. done
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D)
Daughter strands are dispersive. done
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question_answer 75)
Chromatin structure must be altered in order for gene expression to occur because:
A)
Condensed chromatin is replicated but not transcribed. done
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B)
Condensed chromatin makes most DNA sequence inaccessible to the transcription complex. done
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C)
Decondensed chromatin has more nucleosomes per DNA molecule. done
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D)
Heterochromatin is actively transcribed and euchromatin is not transcribed. done
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question_answer 76)
Introns are DNA sequences that:
A)
Code for functional domains in proteins. done
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B)
Are removed from pre-mRNA by spliceosomes. done
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C)
Allow one gene to make different gene products depending on which introns are removed during splicing done
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D)
Both [b] and [c] done
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question_answer 77)
Transcription:
A)
Starts at initiator region and ends at stop region. done
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B)
Starts at operator region and ends at telomeric end. done
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C)
Starts at promoter region and ends terminator region. done
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D)
Starts at CAAT box and ends at TATA box. done
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question_answer 78)
Match column-I with column-II and choose the correct option.
Column-I Column-II A. Exon I. Coding sequence B. Intron II. Cistron C. Genetic code III. Triplet bases on mRNA D. DNA packaging IV. Nucleosome E. V. Non-codding sequence
A)
A-I; B-III; C-II; D-V done
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B)
A-I; B-IV; C-II; D-III done
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C)
A-I; B-V; C-III; D-IV done
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D)
A-IV; B-I; C-V; D-III done
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question_answer 79)
Choose the sequence in which the following enzymes take part in DNA replication.
(i) Helicase (ii) Primase (iii) SSB (iv) DNA polymerase (v) DNA ligase
A)
(i) \[\to \] (v) \[\to \] (iv) \[\to \] (iii) \[\to \] (ii) done
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B)
(i) \[\to \] (ii) \[\to \] (iii) \[\to \] (iv) \[\to \] (v) done
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C)
(i) \[\to \] (iii) \[\to \] (ii) \[\to \] (iv) \[\to \] (v) done
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D)
(i) \[\to \] (iv) \[\to \] (iii) \[\to \] (ii) \[\to \] (v) done
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question_answer 80)
Code transfer for synthesis of polypeptide involves:
A)
DNA, tRNA, rRNA and mRNA. done
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B)
mRNA, tRNA, rRNA and DNA. done
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C)
tRNA, DNA, mRNA and rRNA. done
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D)
DNA, mRNA, tRNA and amino acids. done
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question_answer 81)
Eukaryotic chromosomes:
A)
Are circular and contain origin and terminator sequences. done
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B)
Are linear and have origins and telomeres. done
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C)
Contain coding and non-coding sequences. done
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D)
Both [b] and [c] done
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question_answer 82)
DNA is a genetic material:
(i) Due to its stability. (ii) Its ability to replicate. (iii) Its ability to mutate. (iv) Its ability to express itself. Choose the correct combination.
A)
(i) and (ii) done
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B)
(i), (iii) and (iv) done
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C)
(iii) and (iv) done
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D)
(i), (ii), (iii) and (iv) done
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question_answer 83)
tRNA recognises ribosome by:
A)
\[T\psi C\,\,loop\] done
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B)
DHU loop done
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C)
Anticodon done
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D)
AA-site done
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question_answer 84)
Nucleotide arrangement in DNA can be seen by:
A)
X-ray crystallography done
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B)
Electron microscope done
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C)
Ultracentrifuge done
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D)
Light microscope done
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question_answer 85)
DNA synthesis can be measured by estimating incorporation of radio-labeled:
A)
Uracil done
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B)
Ribose sugar done
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C)
Thymidine done
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D)
Adenine done
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question_answer 86)
During conjugation:
A)
DNA from one bacterial cell is transferred to another bacterial cell using a bacteriophage. done
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B)
Mutants that are auxotrophic for one nutrient can be converted to prototrophs when mixed with mutants that are auxotrophic for another nutrient. done
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C)
A pilus is synthesised and DNA is transferred from one bacterium across the conjugation tube to the recipient bacterium. done
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D)
Both [a] and [b] done
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question_answer 87)
Transposable genetic elements:
A)
Always affect the cell adversely, because when they move, they inactivate genes. done
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B)
Are retroviruses. done
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C)
Provide a mechanism for moving genetic material from organelle genomes to the nuclear genome. done
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D)
Always replicate their DNA when they want. done
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question_answer 88)
The scientists involved in discovery of DNA as chemical basis of heredity were:
A)
Hershey and Chase done
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B)
Griffith and Avery done
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C)
Avery, Mac Leod and McCarty done
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D)
Watson and Crick done
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question_answer 89)
Match column-I with column-II and select the correct combination from the given options.
Column-I Column-II A. Sigma factor I. 5?-3? B. Capping II. Initiation C. Tailing III. Termination D. Codding strand IV. 5? end V. 3?end
A)
A-III; B-V; C-IV; D-II done
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B)
A-II; B-IV; C-V; D-I done
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C)
A-II; B-IV; C-V; D-III done
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D)
A-III; B-V; C-IV; D-I done
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question_answer 90)
Select the incorrect statement(s) about genetic codon.
(i) Six codons do not code for any amino acid. (ii) Codon is read in mRNA in a contiguous fashion. (iii) Three codons function as stop codons. (iv) The initiation codon AUG codes for methionine.
A)
(i) only done
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B)
(ii) only done
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C)
(i), (ii) and (iv) done
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D)
(i), (ii) and (iii) done
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question_answer 91)
Match column-I with column-II and select the correct answer using the codes given below.
Column-I Column-II A. Termination I. Aminoacyl tRNA synthetase B. Translation II. Okazaki fragments C. Transcription III. GTP dependent release factor D. DNA replication IV. RNA polymerase
A)
A-II; B-I; C-III; D-IV done
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B)
A-III; B-I; C-IV; D-II done
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C)
A-IV; B-III; C-I; D-II done
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D)
A-II; B-III; C-I; D-IV done
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question_answer 92)
Co-repressor binds with:
A)
Promoter gene done
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B)
Operator gene done
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C)
Aporepressor done
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D)
Regulator gene done
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question_answer 93)
In lac operon, structural gene 'z' synthesises:
A)
\[\beta \]-galactosidase done
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B)
Galactosidase permease done
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C)
Galactosidase transacetylase done
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D)
None of the above done
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question_answer 94)
E.coli cells with a mutated z gene of the lac operon cannot grow in medium containing only lactose as the source of energy because:
A)
The lac operon is constitutively active in these cells. done
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B)
They cannot synthesise functional beta- galactosidase. done
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C)
In the presence of glucose, E.coli cells do not utilize lactose. done
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D)
They cannot transport lactose from the medium into the cell. done
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question_answer 95)
Which one of the following triplet codes, is correctly matched with its specificity for an amino acid in protein synthesis or as 'start' or 'stop' codon?
A)
UAC-Tyrosine done
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B)
UCG-Start done
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C)
UUU-Stop done
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D)
UGU-Leucine done
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question_answer 96)
Which step of translation does not consume a high energy phosphate bond?
A)
Translocation done
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B)
Amino acid activation done
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C)
Peptidyl-transferase reaction done
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D)
Aminoacyl tRNA binding to active ribosomal site done
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question_answer 97)
One gene one enzyme hypothesis was proposed by:
A)
Khorana and Nirenberg done
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B)
Beadle and Tatum done
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C)
Bateson and Punnet done
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D)
Bridges done
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question_answer 98)
In some viruses, RNA is present instead of DNA indicating that:
A)
Their nucleic acid must combine with host DNA before replication. done
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B)
They cannot replicate. done
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C)
There is no hereditary information. done
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D)
RNA can act to transfer heredity. done
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question_answer 99)
What is the main function of tRNA in relation to protein synthesis?
A)
Initiates transcription done
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B)
Inhibits protein synthesis. done
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C)
Identifies amino acids and transport them to ribosomes. done
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D)
Proofreading. done
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question_answer 100)
In tertiary structure of DNA, what is a histone octamer?
A)
A complex consisting of eight positively charged histone proteins (two of each\[{{H}_{2}}A,{{H}_{2}}B,{{H}_{3}}and{{H}_{4}}\]) that aid in the packaging of DNA. done
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B)
A complex consisting of eight negatively charged histone proteins (two of each\[{{H}_{2}}A,{{H}_{2}}B,{{H}_{3}}and{{H}_{4}}\]) that aid in the packaging of DNA. done
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C)
A complex consisting of nine positively charged histone proteins (\[{{H}_{1}}\]and two of each\[{{H}_{2}}A,{{H}_{2}}B,{{H}_{3}}and{{H}_{4}}\]) that aid in the packaging DNA. done
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D)
A complex consisting of nine negatively charged histone proteins (v\[{{H}_{1}}\] and two of each\[{{H}_{2}}A,{{H}_{2}}B,{{H}_{3}}and{{H}_{4}}\]) that aid in the packaging of DNA. done
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question_answer 101)
Phosphodiester linkage is formed between:
A)
C-5 of one nucleotide and C-3 of the next done
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B)
C-1 of one nucleotide and C-2 of the next done
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C)
Purines of opposite strands done
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D)
Pyrimidines of opposite strands done
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question_answer 102)
From the experiments carried out by Avery, Macleod and McCarty by using various enzymes, which of the following results prominently proved that DNA is the transforming material?
A)
DNA of heat killed 'S' + R type + DNAase \[\to \]virulent strain done
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B)
DNA of heat killed 'S'+R type + RNAase \[\to \]virulent strain done
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C)
DNA of heat killed' S' + R type\[\to \]virulent strain done
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D)
DNA of heat killed 'S'+R type + Protease\[\to \]virulent strain done
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question_answer 103)
A segment of DNA molecule contains 200 guanine and 200 thymine bases. What will be the total number of nucleotides in this segment of DNA?
A)
400 done
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B)
200 done
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C)
800 done
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D)
100 done
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question_answer 104)
In ABO system of blood group there are 4-types of:
A)
Genotypes done
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B)
phenotypes done
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C)
Antibodies done
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D)
alleles done
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question_answer 105)
During elongation of polypeptide chain, sigma factor is:
A)
Functionless. done
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B)
Retained for specific function. done
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C)
Released for re-use. done
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D)
Required during closing of chain. done
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question_answer 106)
Genetic code is:
A)
Triplet, universal, ambiguous and degenerate. done
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B)
Triplet, universal, non-ambiguous and non- degenerate. done
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C)
Triplet, universal, non-ambiguous and degenerate. done
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D)
Triplet, universal, ambiguous and non- degenerate. done
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question_answer 107)
Plasmid DNA contains genes that:
A)
Confer drug resistance to the host cell. done
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B)
Regulate conjugation. done
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C)
Can confer resistance to heavy metals. done
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D)
All of the above done
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question_answer 108)
Who gave the 1st experimental proof of triplet code?
A)
George Gamow done
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B)
Nirenberg done
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C)
Kohenberg done
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D)
Khorana done
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question_answer 109)
Methyl guanosine triphosphate is added at 5' end of hn RNA in a process of:
A)
Tailing done
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B)
Splicing done
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C)
Capping done
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D)
None of these done
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question_answer 110)
The given figure represent one of the step in the process of transcription in bacteria. Identify the step and label A, B & C marked in the figure.
A)
Initiation; A - DNA, B - RNA, C - Promoter done
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B)
Termination; A - RNA, B - RNA polymerase, C - Rho factor done
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C)
Elongation; A - RNA, B - RNA polymerase, C - Sigma factor done
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D)
Elongation; A-DNA, B - DNA polymerase, C - RNA done
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