Answer:
The insertional inactivation of \[\beta -\]galactosidase enzyme, occurs by inserting the desired gene in the coding region of enzyme, which results in inactivation of \[\beta -\]galactosidase gene in recombinants. The recombinant or transformed organisms are unable to produce any colour when grown on chromogenic substrate. Thus, insertional inactivation of an enzyme acts as a selectable marker to differentiate recombinants from non - recombinants.
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