| The diagram shows the reversible conversion of pyruvate to lactate by the enzyme lactate dehydrogenase. |
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| What would be the effect of inhibition of lactate dehydrogenase in a mammalian cell under anaerobic conditions? |
A) A decrease in cell pH, due to the accumulation of lactic acid.
B) A decrease in glycolysis, due to the lack of NAD.
C) An increase in ATP production, due to increased amounts of reduced NAD.
D) An increase in the activity of the Krebs cycle, due to increased amounts of pyruvate.
Correct Answer: B
Solution :
One of the functions of the electron transport chain and the conversion of pyruvate to lactate is the regeneration \[{{\operatorname{NAD}}^{+}}\]from reduced NAD which is needed in glycolysis.
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