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NEET AIPMT SOLVED PAPER SCREENING 2007

  • question_answer
                    During transcription, RNA polymerase holoenzyme binds to a gene promoter and assumes a saddle-like structure. What is it's DNA-binding sequence?                                                                                  

    A)                  TTAA      

    B)                  AATT   

    C)                  CACC      

    D)                  TATA

    Correct Answer: D

    Solution :

                    TATA box is present in eukaryotic promotor region. It has a resemblance with pribnow box of prokaryotes, TATA box was identified by Dr. Hogness and so, it is called as Hogness box. It is a 7 bp long region located 20 bp upstream to the start point. During the process of transcription the RNA polymerase (a holoenzyme which has a core unit and a sigma factor for proper initiation of transcription) binds to TATA box due to which DNA assumes a saddle like structure at this place.


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