A) antithrombin II
B) protein C
C) tissue factor, pathway inhibtor
D) plasmin.
Correct Answer: B
Solution :
: Thrombin is an proteolytic enzyme that converts the soluble protein fibrinogen into the fibrous fibrin during blood clotting. Thrombin is a procoagulant that activates factors V and VIII but when thrombin binds to thrombomodulin it becomes an anticoagulant, in that the thrombomodulin-thrombin complex activates protein C (factor XIV). Activated protein C (APC) along with its cofactor protein S inactivate factor\[V\]and VIII and inactivates an inhibitor of tissue plasminogen activator increasing the formation of plasmin. Plasmin is the active component of the plasmimogen (fibrinolytic) system.
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