A) substitution
B) insertion
C) deletion
D) duplication
Correct Answer: A
Solution :
Sickle-cell anaemia is an autosomal recessive disorder that occurs due to the substitution of glutamate by valine at position- 6 of haemoglobin- \[\beta \]-chain. It occurs due to the point mutation of nucleotide A to T in the codon for amino acid 6 that changed glutamic acid codon (GAG) to valine codon (GTG).
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