A) Haemophilia
B) Haematuria
C) Haematoma
D) Sickle cell anaemia
Correct Answer: D
Solution :
Sickle-cell anaemia is a biochemical disorder inherited as a recessive trait. It concerns with the molecular structure of haemoglobin. Haemoglobin molecule is a tetramer of four polypeptide chains-two identical a-chains and two identical (3-chains. In normal Hb a dominant gene codes for glutamic acid monomer at sixth position in B-cahin. The recessive allele of this gene code for valine in place of glutamic acid at sixth position. In low oxygen tension valine monomers at fist and sixth position become associated in such a way as to change the configuration of haemeoglobin molecules and causing the concerned erythrocyte to become sickle-shaped. Such defective haemoglobin is useless for oxygen trasportation. Haemophilia and colourblindness are X-linked recessive traits. In person suffering from haemophilia blood clotting may take half an hour to twenty four hour due to lack of thromboplastin protein in blood plasma. This persistant bleeding may cause death.
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