A) cirtic acid and succinic acid
B) citric acid and oxaloacetic acid
C) acetyl CoA and succinyl CoA
D) oxaloacetic acid and oxalosuccinic acid.
Correct Answer: C
Solution :
: During aerobic respiration in cells, pyruvate is the end product of glycolysis which enters mitochondria and undergoes oxidative decarboxylation to produce Acetyl \[CoA\], \[C{{O}_{2}}\]and \[NADH\]in the presence of an enzyme complex pyruvate dehydrogenase. \[Pyruv+NA{{D}^{+}}+CoA\xrightarrow[M{{g}^{+2}}]{Pyruvate\,dehydrogenase}\] \[Acetyl-CoA+NADH+{{H}^{+}}+C{{O}_{2}}\uparrow \] During the formation of a-ketoglutarate isocitrate, undergoes oxidative decarboxylation in the presence of enzyme isocitrate dehydrogenase and \[M{{n}^{2+}}\]. A transient oxalosuccinate is formed as intermediate. \[Isocitrate+NA{{D}^{+}}\] \[Oxalosuccinate+NADH+{{H}^{+}}\] \[Oxalosuccinate\xrightarrow{{}}\alpha -ketoglutarate+C{{O}_{2}}\uparrow \] Another decarboxylation occurs in Krebs cycle when a-ketoglutarate is both dehydrogenated and decarboxylated by an enzyme complex a-ketoglutarate dehydrogenase. \[\alpha -ketoglutarate+CoA+NA{{D}^{+}}\xrightarrow{\begin{smallmatrix} \alpha -ketoglutarte \\ \operatorname{dehydrogenase} \end{smallmatrix}}\] Succinyl \[CoA+NADH+{{H}^{+}}+C{{O}_{2}}\uparrow \]
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