CET Karnataka Medical CET - Karnataka Medical Solved Paper-2015

  • question_answer
    A fall in glomerular filtration rate activates

    A)  adrenal medulla to release adrenaline

    B)  juxtaglomerular cells to release renin

    C)  posterior pituitary to release vasopressin

    D)  adrenal cortex to release aldosterone.

    Correct Answer: B

    Solution :

    : A fall in glomerular blood flow/glomerular blood pressure/GFR can activate the JG cells to release renin which converts angiotensinogen in blood to angiotensin I and further to angiotensin II. Angiotensin II, being a powerful vasoconstrictor, increases the glomerular blood pressure and thereby GFR. Angiotensin II also activates the adrenal cortex to release aldosterone. Aldosterone causes reabsorption of \[N{{a}^{+}}\] and water from the distal parts of the tubule. This also leads to an increase in blood pressure and GFR. This complex mechanism is generally known as the Renin-Angiotensin mechanism.


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