A) deletion
B) duplication
C) inversion
D) translocation
Correct Answer: A
Solution :
Cri-du-chat syndrome (Cat-cry syndrome) was discovered by Lejeune in 1963 and is due to the deletion of a large part of the small arm of one of the 5th autosomes. Deletion is a type of mutation in which genetic material is removed from chromosomes or other DNA molecules. Duplication is a type of chromosomal mutation in which part of a chromosome is replicated, so producing extra copies of those genes contained in the duplicated segment, eg, mutation in Drosophila. In inversion, a segment of chromosome becomes reversed and although there is not loss or gain of genetic material, there may be a positive or negative position effect on the phenotype. In translocation, non-homologous chromosomes break and exchange pieces.
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