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JIPMER Jipmer Medical Solved Paper-2007

  • question_answer
    During transcription holoenzyme RNA polymerase binds to a DNA sequence and the DNA assumes a saddle like structure at that point. What is that sequence called?

    A)  CAAT box          

    B)         GGTT box          

    C)         AAAT box          

    D)         TATA box

    Correct Answer: D

    Solution :

    TATA box is present in eukaryotic promoter region. It has a resemblance with pribnow box of prokaryotes. TATA box was identified by Dr. Hogness and so, it is also called as Hogness box. It is a 7 bp long region located 20 bp upstream to the start point. During the process of transcription the RNA polymerase (a holoenzyme which has a core unit and a sigma factor for proper initiation of transcription) binds to TATA box due to which DNA assumes a saddle like structure at this place.


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