A) an autosomal linked dominant trait
B) caused by substitution of valine by glutamic acid in the\[\beta -\]globin chain of haemoglobin
C) caused by a change in base pair of DNA
D) characterized by elongated sickle like RBCs with a nucleus
Correct Answer: B
Solution :
Sickle-cell anaemia is caused by a change in a single base pair of DNA (substitution-of valine by glutamic acid in the P-globin chain of haemoglobin). It is a genetic disease reported from negroes. The individuals of sickle-cell anaemia are immune to malaria.
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