NEET Biology NEET PYQ-Digestion and Absorption

  • question_answer
    If for some reason the parietal cells of the gut epithelium become partially non-functional, what is likely to happen?   [AIPMT (M) 2010]

    A) The pancreatic enzymes and specially the trypsin and lipase will not work efficiently

    B) The pH of stomach will fall abruptly

    C) Steapsin will be more effective

    D) Proteins will not be adequately hydrolysed by pepsin into proteoses and peptones

    Correct Answer: D

    Solution :

    [D] The parietal cells or oxyntic cells are large, -rounded cells located upon the surface of gastric glands. These cells secrete HCl (which converts inactive pepsinogen into active pepsin) and Castle's Intrinsic Factor or CIF (which helps ''in the absorption of vitamin-\[{{\text{B}}_{\text{12}}}\]or cyanocobalamine). If somehow, parietal cells become partially non-functional, the patient will suffer from achlorhydria (no HCl) or hypochlorhydria (less HCl). This will result in the non-activation of pepsinogen due to which proteins will not be adequately hydrolysed into proteoses and peptones. Lack of CIF will cause vitamin-\[{{\text{B}}_{\text{12}}}\] deficiency, which will result in pernicious anaemia.


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