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RAJASTHAN PMT Rajasthan - PMT Solved Paper-2010

  • question_answer
    During transcription, RNA polymerase holoenzyme binds to a gene promoter and assumes a saddle-like structure. What is its DNA-binding sequence?

    A)  TTAA                                   

    B)  AATT

    C)  CACC                   

    D)         TATA

    Correct Answer: D

    Solution :

    TATA box is present in eukaryotic promoter region. It has a resemblance with pribnow box of prokaryotes. TATA box was identified by Dr. Hogness and so, it is called as Hogness box. It is a 7 bp long region located 20 bp upstream to the start point. During the process of transcription, the RNA polymerase (a holoenzyme, which has a core unit and a sigma factor for proper initiation of transcription) binds to TATA box due to which DNA assumes a saddle-like structure at this place.


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