Oswald, Avery, Colin MacLeod and Maclyn
McCarty revealed biochemical nature of the transforming principle.
They reported Griffith's experiment in
an in vitro system in order to determine biochemical nature of transforming
They reported that. DMA from the
neat-killed S-type bacteria caused the transformation of non-virulent R-type
bacteria into virulent S-type bacteria. They also discovered that proteases and
RNase did not affect transformation while DNase inhibited the process. They concluded
that DNA is the hereditary material.
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