12th Class Biology Molecular basis of inheritance

  • question_answer 66)   A single base mutation in a gene may not 'always' result in loss or gain of function. Do you think the statement is correct? Defined your answer.


                      The statement is correct. Because of degeneracy of codons, mutations at third base of codon, usually does not result into any change is phenotype. This is called silent mutations. On other hand, if codon is changed in away that now it specifies another amino acid, it may other the protein function as it happens in case ofb-globulin of hemoglobin protein. Where a substitution of valine instead of glutamic acid causes change in its structure and function and resulting into sickle-cell trait.

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