| Direction: Each of these questions contains two statements |
| Assertion [A] and Reason [R]. Each of these questions also has four alternative choices, any one of which is the correct answer. You have to select one of the codes [a], [b], [c] and [d] given below. |
| Assertion [A] Replication on one strand of DNA is continuous and on another it is discontinuous. |
| Reason [R] The DNA polymerase works in 3' \[\to \] 5' direction |
A) Both A and R are true and R is the correct explanation of A
B) Both A and R are true, but R is not the correct explanation of A
C) A is true, but R is false
D) A is false, but R is true
Correct Answer: A
Solution :
[a] Both A and R are true and R is the correct explanation of A. The DNA-dependent DNA polymerase works in the 5'\[\to \]3' direction requiring a free 3'-OH of a pre-existing polynucleotide for initiating DNA replication. Thus, it continuously synthesises the strand having polarity 3'\[\to \]5'. Replication of the lagging strand (5' \[\to \]3') generates small polynucleotide fragments, okazaki fragments. The replication of this strand is discontinuous.
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