A) increase in size of RBC.
B) deficiency of haemoglobin in RBC.
C) delay in maturation of erythroblasts.
D) None of the above
Correct Answer: A
Solution :
[a] Perniuous anaemia is a chronic illnass, caused by impaired absorption of vitamin \[{{B}_{12}}\] needed to make enough healthy red blood cells. When there is folic acid and vit. \[{{B}_{12}}\] deficiency, the pro-erythroblasts of the bone marrow do not mature into norm oblasts, instead, they give rise to immature cells called mega oblasts which lose their nuclei and appear as large RBC, called macrocytic. In the peripheral circulation, therefore, we find RBC bigger than normal.
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