I. The defect is caused by the substitution of glutamic acid by valine at sixth position of the beta chain of the haemoglobin. |
II. IIeterozygotes \[(H{{b}^{A}}H{{b}^{s}})\] individuals appear apparently unaffected and enjoy some resistance to malaria. |
III. The mutant haemoglobin molecule undergoes polymerization under low oxygen tension causing the change in the shape of the RBC. |
IV Female homozygous for this allele are more fertile than those who lack it. |
A) I and II
B) I, II and IV
C) I, III and IV
D) II, I and III
Correct Answer: D
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