AIIMS AIIMS Solved Paper-2007

  • question_answer
    Patients suffering from cholera are given a saline drip because

    A) \[N{{a}^{+}}\] ions help in stopping nerve impulses and hence, sensation of pain

    B) \[N{{a}^{+}}\] ions help in the retention of water in the body tissues

    C) \[NaCl\] is an important component of energy supply

    D) \[NaCl\] furnishes mot of the fuel required for cellular activity

    Correct Answer: B

    Solution :

    Severe diarrhoea, vomitting, watery stools are the chief symptoms of cholera. All these lead to dehydration. Actually, cholera toxin secreted by Vibrio cholerae causes, through a series of metabolic reactions, the continuous activation of adenylate cyclase of intestinal epithelial cells. The resultant high concentration of c-AMP triggers continuous secretion of \[C{{l}^{-}},\,HCO_{3}^{-}\]and water into the lumen of the intestine. Administration of saline not only supports the sodium-potassium pump through which water in cell is restored, but glucose is also symported along with sodium.


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