D) restriction endonuclease
Correct Answer: D
Solution :Restriction endonuclease is a class of endonucleases which cleaves double stranded DNA at specific base sequences, called restriction sites. W. Arber postulated the presence of restriction enzymes, while first true restriction endonuclease was isolated in 1970 by Smith et. al., for which they were awarded Nobel Prize in 1978.
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