NEET AIPMT SOLVED PAPER SCREENING 2011

  • question_answer
    What are those structures that appear, as 'beads-on-string' in the chromosomes when viewed under electron microscope?

    A) Nucleotides   

    B)        Nucleosomes

    C)        Base pairs      

    D)        Genes

    Correct Answer: B

    Solution :

    Nucleosome is sub-microscopic sub-unit of chromatin which is formed by wrapping of DNA over a core of histone proteins. The term was coined by Oudet et. al, (1975). It is oblate structure with a length of 10 nm and a thickness of 5-5.7 nm. Its core is called nu-body. The latter is formed of four pairs of histone molecules-\[{{H}_{2}}A,\]\[{{H}_{2}}B,{{H}_{3}}\] and \[{{H}_{4}}\] DNA makes 1.75 turns over the octamer to form a nucleosome. Two adjacent nucleosomes are connected by a short segment of unbound DNA called linker DNA.A fifth type of histone called \[{{H}_{1}}\] is attached over the linker DNA. Nucleosomes appear as 'beads-on-string' in the chromosomes under electron microscope.


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