A) receptors on motor end plate are reduced
B) secretion from nerve terminals is reduced
C) esterase activity is inhibited
D) secretion from nerve terminals is enhanced
Correct Answer: A
Solution :
Myasthenia gravis is an autoimmune neuromuscular disease leading to fluctuating muscle weakness and fatiguability. It is an autoimmune disorder, in which weakness is caused by circulating antibodies that block acetylcholine receptors at the post-synaptic neuromuscular junction, inhibiting the stimulative effect of the neurotransmitter acetylcholine. Myasthenia is treated medically with cholinesterase inhibitors or immune suppressants and in selected cases, thy mectomy. At 200-400 cases per million, it is one of the less common autoimmune disorders. It must be distinguished from congenital my asthenic syndromes that can present similar symptomatology but offer no response to immunosuppressive interventions.
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