A) Have genotype \[H{{b}^{s}}/H{{b}^{s}}\]
B) Have genotype \[H{{b}^{A}}/H{{b}^{A}}\]
C) Substitution of glutamic acid to valine
D) Have sickle-shape RBC
Correct Answer: B
Solution :
Genotype \[H{{b}^{A}}/H{{b}^{A}}\] is normal haemoglobin is no sickling. \[H{{b}^{s}}/H{{b}^{s}}\] genotype means haemoglobin s only sickling under normal oxygen tension in sickle cell anaemia glutamic acid at 6th position is replaced by valine amino aced. In this disease RBCs show a marked change in their structure attaining a sickle shaped structure.
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