Directions : In the following question more than one of the answers given may be correct. Select the correct answer and mark it according to the code:
Link between glycolysis, Krebs' cycle and \[\text{ }\!\!\beta\!\!\text{ -}\]oxidation of fatty acid or carbohydrate and fat metabolism is (1) Acetyl CoA (2) a compound formed by oxidative de-carboxylation (3) a 2-carbon compound (4) oxaloacetic acidA) 1,2 and 3 are correct
B) 1 and 2 are correct
C) 2 and 4 are correct
D) 1 and 3 are correct
Correct Answer: A
Solution :
Before entering the Krebs' cycle, pyruvic acid (3C compound formed by glycolysis) converts into acetyl Co-A (2C compound) by the process of oxidative decarboxylation as follows \[\underset{\text{(3}\,\text{Carbon)}}{\mathop{\text{Pyruvic}\,\text{acid}\,\text{+}\,\text{CO}\,\text{-}\,\text{A}\,\text{+}\,\text{NADT}\xrightarrow[\text{Lipoic}\,\text{acid}]{\text{TPP,}\,\text{M}{{\text{g}}^{\text{2+}}}}}}\,\] \[\underset{\text{(2}\,\text{Carbon)}}{\mathop{\text{Acetyl}\,\text{Co-A}\,\text{+}\,\text{NAD}{{\text{H}}_{\text{2}}}\,\text{C}{{\text{O}}_{\text{2}}}}}\,\] This reaction is commonly called link reaction or Gateway step and aceiyl Co-A is called connecting link between glycolysis and Krebs cycle.
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