Directions : In the following question more than one of the answers given may be correct. Select the correct answer and mark it according to the code:
Factor(s) that raises \[{{\text{P}}_{\text{50}}}\] value and shift the HbO2 dissociation curve to right and vice versa is/are (1) rise in \[{{\text{P}}_{C{{O}_{2.}}}}\] (2) rise in H+ ions (3) rise in diphosphoglyceric acid (4) rise in pH but fall in temperatureA) 1, 2 and 3 are correct
B) 1 and 2 are correct
C) 2 and 4 are correct
D) 1 and 3 are correct
Correct Answer: A
Solution :
A rise in body temperature, concentration of 2, 3-diphosphoglycerate (DPG) in RBCs or \[{{\text{P}}_{\text{C}{{\text{O}}_{\text{2}}}}}\] or a fall in blood pH (increase in H+ decreases \[{{O}_{2}}\] affinity of haemoglobin, revising \[{{\text{P}}_{50}}\] and shifting the \[{{O}_{2}}\] haemoglobin dissociation curve to the right.
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