BHU PMT BHU PMT (Screening) Solved Paper-2005

  • question_answer
    Fist biochemical to be produced commercially  by microbial cloning and genetic engineering, is:

    A)  human insulin                  

    B)  penicillin

    C)  interferons                       

    D)  fertility factor

    Correct Answer: A

    Solution :

                     Biotechnology is the technological exploitation of biological processes including genetic engineering for obtaining useful materials for industry, domestic, medical. Human insulin is composed of A and B chain of amino acid connected by two S-S linkages. In 1983 American company Eli Lilly prepared two DNA sequences corresponding to A and B insulin chains. These chains are formed by bacteria E.coli through recombinant DNA technology. After fusion of both polypeptide chain humulin is produced. Humulin is the first biochemical to be produced by genetic engineering. Penicillin is the first antibiotic which is isolated from a fungus Penicillium notatum by Alexander Flemming. Inter fcrons are proteinaceous substances which are produced by virus infecting host cells and they are antiviral agent. Fertility factor is a plasmid (extra chromosomal genetic material) of bacteria which helps in genetic recombination.


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