A) 22 A + XXY
B) 22 A + XO
C) 22A + XY
D) 22 A + XX
Correct Answer: A
Solution :
Klinefelter's syndrome is a human sex abnormality, arises due to non-disjunction of sex chromosomes during meiosis. It is characterised by the chromosome number. \[2n=47,\]the chromosomal formula is \[\text{44}\,\text{A}\,\text{+}\,\text{XXY}\text{.}\] Klinefelter's syndrome is a male in general appearance; testes are underdeveloped, enlarged breast (gyneco mastia), Mentally defective and abnormally tall. Mental retardation increases with X complement. The karyotypes of extreme Klinefelter's syndrome are \[\text{44}\,\text{A}\,\text{+}\,\text{XXXY}\text{.}\] \[\text{44}\,\text{A}\,\text{+}\,\text{XXXXY,}\]\[\text{44}\,\text{A}\,\text{+}\,\text{XXXYY,}\] etc. In Turner syndrome, chromosome number is \[2n=45.\] The chromosomal formula is \[\text{44}\,\text{A}\,\text{+}\,\text{XO}\text{.}\] She is a sterile female. \[\text{22}\,\text{A}\,\text{+XY}\] is chromosome constitution of normal male individuals which are heterogametic. \[\text{22}\,\text{A}\,\text{+XX}\]is chromosome constitution of normal female individuals, are homogameric.
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