CET Karnataka Medical CET - Karnataka Medical Solved Paper-2012

  • question_answer
    Chemiosmotic theory of ATP synthesis in the mitochondrion is based on

    A)  \[C{{a}^{++}}\] gradient    

    B)  \[{{K}^{+}}\] gradient

    C)  \[{{H}^{+}}\] gradient      

    D)  \[N{{a}^{+}}\] gradient.

    Correct Answer: C

    Solution :

    : Chemiosmotic theory was postulated by y the British biochemist Peter Mitchell (1920-92) to explain the formation of ATP in the mitochondrial electron transport chain. As electrons are transferred along the electron carrier system in the inner mitochondrial membrane, hydrogen ions (\[{{H}^{+}}\] or protons) are actively transported (by proton pumps) into the space between the inner and outer mitochondrial membranes, which thus contains a higher concentration of protons than the matrix. This creates an electrochemical gradient across the inner membrane, down which protons move back into the matrix. This movement occurs through special channels associated with ATP synthetase, the enzyme that catalyzes the conversion of ADP to ATP, and is coupled with the phosphorylation of ADP.


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