DUMET Medical DUMET Medical Solved Paper-2003

  • question_answer
    During protein denaturation which of the following is disrupted?

    A)  2D structure

    B)  3D structure

    C)  Peptide bond

    D)  AA sequence

    Correct Answer: B

    Solution :

    The conformational change that produces biologically inactive form of protein is called denaturation. Denatured proteins usually form large aggregates that are precipitated from solution. This process is called coagulation. During denaturation the 3-D structure of proteins is disrupted by breaking of disulphide bridge. During denaturation no peptide bonds are broken. The conditions or chemicals which bring about denaturation are heat, organic solvents, acid and bases, salt of heavy metal ions, etc.                   The number and sequence of amino acids in the polypeptide chain constitute the primary structure.


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