DUMET Medical DUMET Medical Solved Paper-2004

  • question_answer
    Sporogony of malarial parasite occur in :

    A)  liver of man

    B)  stomach wall of mosquito

    C)  RBCs of man

    D)  salivary gland of mosquito

    Correct Answer: B

    Solution :

    Asexual cycle of Plasmodium vivax is operated in human while the sexual cycle in female Anopheles mosquito. The life cycle is studied under following headings. (i) Liver schizogony: Sporozoite (infective stage) present in the saliva of mosquito are introduced in human blood stream and enters into liver cell. During pre-erythrocytic phase the Sporozoite becomes cryptozoite and divide to form cryptomerozoite.    During  exo-erythrocytic phase the cryptomerozoite. rise to large number of metacryptomerozoites. (ii)    Erythrocytic   stage: The metacryptomerozoites enters the red blood corpuscles and transformed to trophozoites, which undergoes Signet ring stage. Their enzyme   bring   about   proteolysis   of haemoglobin into protein and hematin. The hematin forms the toxic material haemozoin. The trophozoite develop to become schizont which changed to merozoite. Few merozoites form   gametocytes   (mega   and   micro gametocyte) (iii) Sexual cycle in mosquito: The gametocytes are ingested by female Anopheles mosquito from infected person. The fusion of microgamete and macrogamete forms the zygote which later known as ookinite. The ookinite penetrates through wall of midgut become encysted and called oocyst. Each oocyst  enter a phase of asexual multiplication known as sporogony. About 10,000 minute sporozoites are formed from oocyst.


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