JIPMER Jipmer Medical Solved Paper-2007

  • question_answer
    Haemophilia is more commonly seen in human males than in human females because

    A)  this disease is due to an X-linked dominant mutation

    B)  a greater proportion of girls die in infancy

    C)  this disease is due to an X-linked recessive mutation

    D)  this disease is due to a Y-linked recessive mutation

    Correct Answer: C

    Solution :

    Haemophilia, a hereditary (recessive X-linked) disease is caused due to fault in genes, which controlling the factor VIII and K, located on X-chromosome. The male carries only one X-chromosome, his other sex chromosome, which carries no genes for blood clotting, so the condition is usually seen only in males where only one faulty chromosome is needed. While a female with one faulty X-chromosome will be carrier. So, in females two faulty X-chromosomes are needed to cause the disease.


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