JIPMER Jipmer Medical Solved Paper-2007

  • question_answer
                                                                        Which one of the following hydrolysis internal phosphodiester bonds in a polynucleotide chain?

    A)  Lipase                 

    B)         Exonuclease     

    C)         Endonuclease                  

    D)         Protease

    Correct Answer: C

    Solution :

    DNAase (or deoxyribonuclease) or simply nuclease is an enzyme which breaks down DNA by hydrolysis of the phosphodiester bonds of its sugar-phosphate back bone. Depending on the position of hydrolyzing phosphodiester bonds, nucleases are of two types: (i) Endonucleases (ii) Exonucleases. Endonucleases hydrolyse internal phosphodiester bonds in a polynucleotide chain (.i.e., DNA). While exonucleases hydrolyse terminal phosphodiester bonds in a polynucleotide chain (.i.e., DNA).


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