VMMC VMMC Medical Solved Paper-2015

  • question_answer
    A sequence is given to a student was CAG TAG CAG TAG CAG TAG. The student rewrite the sequence as CAG ATA GCA GTA GCA GTA G. What has happened in this sequence?

    A) Deletion              

    B) Insertion

    C) Frame shift                        

    D) Point mutation

    Correct Answer: B

    Solution :

    Insertion of a base adenine has occured in the original sequence \[\underset{\begin{smallmatrix}  \,\,\,\,\,\,\,\,\,\,\,\,\,\,\,\,\,\,\,\,\,\,\,\,\,\,\,\,\,\,\,\,\,\,\,\,\text{ }\!\!'\!\!\text{ A }\!\!'\!\!\text{ } \\  \text{CAG}\,\text{ATA}\,\text{GCA}..... \end{smallmatrix}}{\overset{\text{CAG}\,\text{TAG}.....}{\mathop{\uparrow }}}\,\] Insertion of 'A' has shifted the reading frame. Insertion is the addition of one or more nitrogenous bases to the nucleotide chain, changing the complete reading frame.


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