A) P - Extrinsic factor and Q - Stomach
B) P - Intrinsic factor and Q - Stomach
C) P - Intrinsic factor and Q - Small intes
D) P- Exopolysaccharide and Q-Smail intestin
Correct Answer: B
Solution :
Vitamin \[-{{B}_{12}}\] also called cobalamin is a water soluble vitamin with a key role in the normal functioning of brain and nervous system and also for the formation of blood. Intrinsic Factor (IF) also known as gastric Intrinsic Factor (GIF), is a glycoprotein produced by the parietal cells of the stomach. It is present in the gastric juice as well as gastric mucous membrane. It is necessary for the absorption of vitamin \[-{{B}_{12}}\] later on in the small intestine. In humans, the gastric intrinsic factor protein is encoded by the GIF gene. Upon entry into the stomach, vitamin-B^ 3 becomes bound to haptocorrin (a glycoprotein.) The resulting complex enters the duodenum, where pancreatic enzymes digest haptocorrin. In the less acidic environment of the small intestine, \[{{B}_{12}}\]can then bind to intrinsic factor. This new complex thus, travels to the ileum, where special epithelial cells endocytose them. Inside the cell, \[{{B}_{12}}\]dissociates once again and binds to another protein. The new complex can thus, exit the epithelial cells to enter the liver.
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