| (i) It is an autoimmune disorder. |
| (ii) It causes insufficient acetylcholine binding that affects muscular contraction. |
| (iii) Antibodies are developed against acetylcholine. |
| (IV) Antibodies are developed Against acetylcholine receptors. |
| (V) Antibodies are developed against acetylcholine esterase. |
| (VI) It causes drooping of eyelids. |
A) I, III, IV, VI
B) I, III, IV, VI
C) I, II, IV, VI
D) II, III, IV, V
Correct Answer: C
Solution :
Statements (I), (II), (IV) and (VI) are correct. Myasthenia gravis is an autoimmune neuromuscular disease that or congentital. Leads to muscle weakness. It is caused by circulating antibodies that block acetylcholene receptors at the post-synaptic neuromuscular junction inhibiting the excitatory effects of acetyl choline and nicotinic receptors at neuromuscular junctions. First noticeable symptom is weakning of eye muscles leading to drooping of eyelids. It is treated medically with acetylcholine esterase inhibitiors or immuno suppressants.
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