Current Affairs 12th Class

Homeostasis (Gk, homoios = same; stasis = standing) is the maintenance of a constant internal environment or steady state (blood plasma, haemolymph, extracellular fluid, etc.). The French physiologist Claude Bernard (1857) realized the importance of stability in the internal environment (milieu interieur). The term 'homeostasis' was first coined by the American physiologist Walter Bradford Cannon in 1929. Homeostasis is a fundamental property of life and is considered a good sign of life.

Growth is one of the most important characteristics of living organisms. Growth is defined as a permanent increase in size or weight or volume of an organism or its body parts e.g. kittens grow into cats, pupies grow into dogs and a human baby grows to become adult. At the molecular level, the growth involves, (1) Increase in the size of cells due to synthesis of protoplasmic substances like cytoplasm and nucleus. (2) Addition of non-living aprotoplasmic materials like intercellular matrix, fibres of connective tissue, etc. These are secreted by the cells. (3) Increase in the number of cells by cell division. It occurs through cell cycle which is formed of interphase and M-phase. (4) Growth is the result of greater anabolic (synthetic) processes over the catabolic (destructive) processes in an organism. The process in which reserve food material is utilized and exhibited negative growth is called degrowth.

(1) Energy Transformation : It is the phenomenon in which one form of energy is changed into another form of enrgy. e.g. in photosynthesis (anabolism), radiant (Kinetic) energy of sunlight is changed into chemical (potential) energy of glucose. All the living organisms depend upon this transformation. (2) Energy Transfer : It involves the movement of energy from one source or area or substance to another in the same form. e.g. in cell respiration (catabolism), oxidative break down of glucose occurs inside the mitochondria of aerobic plants and animals. The glucose is enzymatically catabolised by stepped breakdown into water and \[C{{O}_{2}}\] and about 686 kcal of energy is released per mole of glucose. A part of released energy is stored as chemical energy in high energy bonds of ATP (adenosine triphosphate) formed by phosphorylation of ADP.     Some examples of Energy transformation.
Type of Energy Transformation Example
 Chemical to electrical Nerve cell
 Light to electrical Retina of eye
 Chemical to osmotic Kidney
 Chemical to mechanical Muscles and cilia
 Sound to electrical Ear
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(1) In general, growth involves three processes or strategies namely cell proliferation, cell enlargement and secretion of large amount of extracellular matrix. (2) Growth is an important part of development, continuing throughout life. (3) Early embryonic developmental stages constitute prefunctional state of life. (4) The biological process of growth and differentiation enables the animal to enter the functional state of life. (5) Morphogenesis refers to generation of form and structure during development of an individual organism. (6) Morphogenesis produces new forms by involving cell movements. (7) Morphogenetic movements of large number of cells during development is particularly noticed during gastrulation. (8) Differentiation results in increasing diversity of cells.

Death is the permanent breakdown and finally stopping of vital functions of body, especially heart beat and respiration. Characteristics (1) It is the last event in the degenerative processes of ageing. (2) Death involves widespread be cell breakdown and cell death. (3) Death of an organism involves the death of body cells. But all the body cells do not die at same rate e.g. ciliated cells lining the respiratory tract of mammals continue to beat their cilia for long time even after clinical death. (4) There is no natural death in some protists e.g. Amoeba and monerans like bacteria, etc.

Living organism is formed of many types of inorganic as well as organic biomolecules. Inorganic compounds include water, minerals etc. and are always micro-biomolecules (small sized, low molecular weight, readily soluble in water and diffusible) while organic molecules may be micro (e.g. monosugars, amino acids etc.) or macro-biomolecules (large sized, high molecular weight, insoluble or slightly soluble and non-diffusible e.g., proteins, fats, nucleic acids, etc.). These Both types of biomolecules play important roles in metabolism : (1) Role of Water : Water forms 70-90% of the cellular pool. It forms 65% (about two-thirds) of human body. It is formed of H and O in the ratio of 2:1. 95% of water is found in free state and 5% in combined form in the cell. Water helps in sustaining the life processes. So water is called elixir or cradle of lip as life is not possible in the absence of water. (2) Role of Oxygen : Oxygen is mainly utilized in aerobic cell respiration of the nutrients inside the mitochondria to produce energy-rich ATP molecules so is essential for life. In the absence of oxygen, only 5% of energy available is released. (3) Role of Sodium chloride (common salt -\[NaCl)\] : Sodium chloride plays important roles in metabolic functions of body especially when in ionic form. (4) Role of Carbohydrates : Carbohydrates are organic compounds formed of C, H and O generally in the ratio of 1:2:1. These are commonly called saccharides (Gk. saccharon = sugar) Carbohydrates are the main storage molecules and most organisms use carbohydrates as an important fuel, breaking these bonds and releasing energy to sustain life. (5) Role of Proteins : Proteins are polymeric compounds formed by interlinking of amino acids (monomers) by peptide bonds. Out of about 100 types of amino acids, only 20 types of amino acids are of biological importance, so are called Magic-20. Proteins play a vital role in the formation of structures in living organisms. Like carbohydrate and fat, protein can be broken down with the release of energy. Protein is not stored as such in the body and it is normally only used as a substantial source of energy in conditions of starvation. (6) Role of lipids : Lipids comprise a major group of insoluble hydrocarbons having many functions. These are polymers of alcohols (e.g. glycerol) and fatty acids interlinked by esterbonds. Complex lipids such as true fats are important organic molecules that are used to provides energy. Fats in animals also provide protection from heat loss. (7) Role of Nucleic Acid : These are polymers of nucleotides interlinked by phosphodiester bonds, so called polynucleotides. Each nucleotide is formed of 3 components : a pentose sugar (e.g. ribose in RNA and deoxyribose in DNA), a phosphate group and an inorganic nitrogen-base (a purine or a pyrimidine). DNA acts as genetic material in most organisms and controls the synthesis of structural and functional proteins. RNA also act as genetic material in all plant viruses e.g. TMV and helps in protein synthesis.

Living beings are called organisms. Living organisms are similar to non-living objects in being ? formed of similar elements which combine in similar way to form similar molecules (called biomolecules in living organisms) and follow similar physical and chemical laws like gravitation, magnetism, action and reaction etc. living organisms show a great biodiversity and are classified into different kingdoms-Monera, Protista, Fungi, Plantae and Animalia. But all of these share the following properties ? (1) They have definite organisation.        (2) They always have cellular nature so are either unicellular (e.g. Amoeba, Paramecium etc.) or multicellular (e.g., Hydra, man etc.). (3) They show co-ordination between different parts of body to maintain homeostasis (constant internal environment) inside the body. (4) They have the ability of movements and locomotion. (5) They show metabolic functions in the presence of energy. (6) These have the ability of intussusceptional  (internal) growth and development. (7) These have specific receptors (e.g., sense organs to receive external and internal stimuli) and specific effectors (e.g., muscles and glands to give specific response). (8) These have regulatory mechanisms (e.g., nerves and hormonal in animals, and only hormonal in plants) to maintain homeostasis inside the body. (9) These show adaptations to their environment to increase their chances of survival. (10) These show variations which help in speciation and evolution. (11) These have reproductive powers for continuity of their race. (12) These have definite life span (period from birth to death). (13) These undergo ageing after adulthood and then natural death.

(1) Adaptation may be defined as any characteristic of an organisms which makes the organisms better suited to its environment. (2) In other words, an adaptation improves the performance and survival of the organism in its the environment. (3) Many adaptations are remarkable; they result from natural selection. (4) Individuals with favourable characteristics replace those with less favourable characteristics. (5) Adaptation improves the match between organisms and their environment. (6) On the basis of their nature and role in evolution the adaptation are classified into short range or temporary and long range or permanent adaptation.   Differences between Short-range and Long-range adaptation
Characters Short-range adaptations Long-range adaptations
 Nature These are temporary changes. These are permanent changes.
 Development These are developed in response to temporary changes in the environment. These are developed in response to permanent change in the environement.
 Transmission These are not inheritable. These are inheritable.
 Genetic material DNA is not changed. DNA is also changed.
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Central dogma of molecular biology proposes a unidirectional or one way flow of information from DNA to RNA (transcription) and from RNA to protein (translation). The concept was given by Watson and Crick.   \[\text{DNA}\xrightarrow{\text{Transcription}}\text{mRNA}\ \xrightarrow{\text{Translation}}\ \text{Protein}\]   As mentioned above the first step of central dogma is transcription (synthesis of mRNA from DNA), but in case of reverse transcription DNA is synthesizes from RNA in retrovirus. That concept is given by Temin and Baltimore in Rous sarcoma virus, also known as teminism or reverse transcription and enzyme catalyze this reaction is reverse trancriptase or RNA dependent DNA polymerase. For this work, Temin, Baltimore and Dulbecco were given Nobel prize (1975).   \[\text{DNA}\underset{\xleftarrow[\text{Reverse}\,\text{Transcription}]{}}{\mathop{\xrightarrow{\ \ \ \ \text{Transcription}\ \ \ \ \ }}}\,\text{RNA}\xrightarrow{{}}\text{Protein}\]

The chromosomes are capable of self-reproduction and maintaining morphological and physiological properties through successive generations. They are capable of transmitting the contained hereditary material to the next generation. Hence these are known as 'hereditary vehicles'. The eukaryotic chromosomes occurs in the nucleus and in certain other organelles, and are respectively called nuclear and extranuclear chromosomes. Discovery of chromosomes Hofmeister (1848) : First observed chromosomes in microsporocytes (microspore mother cells) of Tradescantia. Flemming (1879) : Observed splitting of chromosomes during cell division and coined the term, ‘chromatin’. Roux (1883) : He believed the chromosomes take part in inheritance. W.Waldeyer (1888) : He coined the term 'chromosome'. Benden and Boveri (1887) : They found a fixed number of chromosomes in each species. Chromosomal theory of inheritance It was proposed independently by Sutton and Boveri in 1902. The chromosome theory of inheritance proposes that chromosomes are vehicles of hereditary information and expression as Mendelian factors or genes. Kinds of chromosomes Viral chromosomes : In viruses and bacteriophages a single molecule of DNA or RNA represents the viral chromosome. Prokaryotic / Bacterial chromosomes : In bacteria and cyanobacteria, the hereditary matter is organized into a single large, circular molecule of double stranded DNA, which is loosely packed in the nuclear zone. It is known as bacterial chromosome or nucleoid. Eukaryotic chromosomes : Chromosomes of eukaryotic cells are specific individualized bodies, formed of deoxyribonucleo proteins (DNA + Proteins). Number of chromosomes The number of chromosomes varies from two, the least number an organism can have, to a few hundred in different species. The least number of chromosomes are found in Ascaris megalocephala i.e., 2 (\[n=2\]in Mucor hiemalis in plants) while in a radiolarian protist (Aulocantha) has maximum number of chromosomes is 1600 (Ophioglossum reticulatum, 2n = 1262 in plants). The male of some roundworms and insects have one chromosome less than the females.   Diploid number of chromosomes in some organisms
Common name Scientific name Chromosomes
Amoeba Amoeba proteus 500
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