Current Affairs 12th Class

The main non-communicable diseases are diabetes, inflammatory diseases of joints such as arthritis, gout, cardiovascular diseases and cancer. (1) Diabetes Mellitus (i) Diabetes is characterised by chronic hyperglycemia which is excessive concentration of glucose in the blood. (ii) Diabetes is primarily a result of relative or complete lack of insulin secretion by the \[\beta \] cells of islets of Langerhans in pancreas. (iii) Diabetes is established by blood and urine sugar levels. (2) Arthritis (i) Arthritis is any inflammatory condition of the joints characterised by pain and swelling. (ii) Two kinds of arthritis are : rheumatoid arthritis and osteoarthritis. (iii) There is no cure for arthritis; drugs are available which relieve pain. (iv) Rheumatoid arthritis is characterised by inflammation of the synovial membrane. (v) A kind of rheumatoid arthritis that occurs in younger people is Still’s disease. (vi) Osteoarthritis is a disease common among the elderly persons resulting from erosion of articular cartilage. (vii) Paraplegia refer to weakness or paralysis of both legs, often accompanied by loss of sensation. (viii) Paraplegia is usually caused by a motor vehicle accident, sports accident, fall or gunshot wounds. (3) Gout (a) Gout results from accumulation of uric acid crystals in the synovial joints. (b) Gout is a disease associated with an inborn error of uric acid metabolism that increases production or interferes with the excretion of uric acid. (4) Cardiovascular Diseases (a) Cardiovascular diseases refer to a number of diseases associated with the blood vascular system. (b) Some major cardiovascular diseases are rheumatic heart disease, hypertensive heart disease and coronary heart disease. (i) Rheumatic heart disease Rheumatic heart disease is an autoimmune disease, most common in children after a severe throat infection by certain strain of Streptococcus bacteria. An antigen on the surface of these bacteria is very similar to an antigen on the surface of myocardium. The antibodies against Streptococcus may react with myocardium and cause heart difficulties. (ii) Hypertensive heart disease Hypertensive heart disease are caused by hypertension, i.e., increased blood pressure. Serious hypertension is a common cause of chronic heart failure particularly in older people. (iii) Coronary heart diseases Coronary heart diseases are characterised by impaired heart function due to inadequate blood flow to the heart. Angina pectoris is the chest pain caused most often by myocardial anoxia. Attacks of angina pectoris are often related to exertion, emotional disturbance and exposure to excess cold. Myocardial infarction is commonly called coronary or heart attack. Coronary heart disease may be due to raised serum cholesterol, cigarette smoking, high blood pressure, physical inactivity, obesity and diabetes. Cyanosis refers to a bluish coloration of the skin and mucous membranes due to too much deoxygenated haemoglobin in the blood. (5) Cancer : Cancer is an abnormal and uncontrolled division of cells, known as cancer cells, that invade and destroy the surrounding tissues. Generally Cancer is defined as uncontrolled proliferation of cells without any differentiation. Cancer cells are different from normal cells in some aspects. They do not remain confined to one part of the body. more...

Meaning : The diseases which are caused by pathogens (viruses and living organisms) and readily spread from the infected to the healthy persons are called communicable or infectious diseases. A German physician, Robert Koch, listed the following four conditions to establish that a specific pathogen causes a particular disease - (1) The suspected pathogen should be invariably present in the animals suffering from the disease and should not be found in healthy individuals. (2) The pathogens isolated from the diseased animal should be grown in a pure culture. (3) When this culture is inoculated into a healthy host, the latter should develop the disease and show its characteristic symptoms. (4) The pathogen should be recoverable from the experimental host, and it should be the same as the original one. Kotch’s postulates proposed for animal diseases, hold good for human diseases also. However, his conditions do not apply to viruses because they cannot be cultured on artificial media. Classification of communicable Diseases : The communicable diseases are classified into seven types according to the nature  of their causative agent. (1) Viral Diseases : These are caused by viruses. They include chickenpox, smallpox, influenza, common cold, measles, mumps, polio, rabies, yellow fever, and sinus infections. The viruses are named after the disease they cause. (2) Rickettsial Diseases : These are caused by rickettsias, the obligate intracellular parasitic organisms. They include Rocky Mountain spotted fever, typh’s fever, trench fever and Q fever. (3) Bacterial Diseases : These are caused by bacteria. They include diphtheria, scarlet fever, tetanus, typhoid fever, tuberculosis, anthrax, cholera, food poisoning, and meningitis. (4) Spirochaetal Diseases : These are caused by spirochaetes, the long, spiral, corkscrew-shaped bacteria. They cause syphilis. (5) Protozoan Diseases : These are caused by protists. They include amoebic dysentery, malaria, kala-azar, oriental sore and sleeping sickness. (6) Fungal Diseases : These are caused by fungi, the non-green heterotrophic organisms. They include ringworm and athlete’s foot. (7) Helminthes Diseases : These are caused by helminthes, i.e., flatworms and roundworms. They include liverrot, schistosomiasis, taeniasis and cysticercosis produced by flatworms; and ascariasis, enterobiasis, filariasis (elephantiasis), trichinosis, Guinea worm disease and hookworm disease caused by roundworms. Important diseases caused by Viruses : (1) Influenza : Influenza, commonly called flu, is a highly infectious disease, which has still not been conquered. It is caused by many kinds of viruses, such as myxovirus. The latter affect the mucous membrane of nose, throat and upper respiratory tract. The common symptoms are discharge from the nose, sneezing, fever, body aches, coughing and general weakness. Influenza generally lasts for 4 or 5 days. Rest quickens the recovery. There is no vaccine for influenza. Influenza tends to occur in epidemic or pandemic form with varying virulence. (2) Chickenpox : It is a common, relatively mild, highly contagious disease of children, generally under 10 years of age. It is caused by a virus called chickenpox virus (varicella zoster). Fever, aches and general discomfort are the symptoms. Dewdrop-like sores appear in successive crops, first on the trunk. more...

History of Vaccines and Vaccination : In vaccination weakened or dead pathogens, or portions of pathogens, are injected into a person who is required to be made immune. The pathogens given in a vaccine are unable to cause the disease, but are sufficient to stimulate the formation of antibodies by host’s cells. The process of vaccination was initiated by Edward Jenner in 1790. He observed that milkmaids did not contract smallpox apparently because they were exposed to a similar but milder form of disease called cowpox. Edward Jenner infected first James Phipps,, a healthy boy of about 8 years with cowpox and two months later he infected the boy with smallpox. The boy did not suffer from small pox. Jenner proposed that an induced mild form of a disease would protect a person from a virulent form (which has ability to damage the host). He used the term vaccine (in Latin Vacca means ‘cow’) and the term vaccination for protective inoculation. Edward Jenner was the first to discover a safe and effective means of producing artificial immunity against small pox. Thus once vaccination is done the individual is protected from the disease. Vaccination develops acquired immunity. Pasteur confirmed Jenner’s findings and produced vaccines for other diseases like anthrax, rabies and chicken cholera. For protection need : Antibody provoking agents are called vaccines. These are used against viral and bacterial diseases. Calmette & Guerin developed BCG vaccine for T.B. and Salk made Polio vaccine. Sabin also prepared Polio vaccine. Enders developed vaccine against measles. WHO was formed in 1948 at Geneva to take health problems at global level. In May, 1974, Global Immunisation Programme was launched by WHO for six disease (Diphtheria, Pertussis, Tetanus, Measles, TB & Polio). Vaccination : It is the possible way to induce active acquired immunity against the germs of various diseases such as polio, diphtheria, whooping cough, tetanus and small pox. The immune system is thus induced to produce antibodies against these antigens. The artificial introduction of disease factors in the body is known as vaccination. Usually 2-3 injections are given to achieve full immunity against a specific pathogen and the further dose is called as booster doses. Other Vaccines : Vaccines are also available for diphtheria, tetanus, whooping cough, tuberculosis, measles, polio, mumps, plague. Types of Vaccines (1) Killed vaccine : These vaccines are prepared by killing the pathogenic organisms by heat uv-rays/alcohol formalin/phenol, e.g., Typhoid Vaccine, Cholera Vaccine. (2) Toxoid : These are prepared by destroying the toxic property of the toxins produced by organisms but retaining its antigenic property, e.g., Tetanus toxoid, Antidiphtheria toxoid. (3) Attenuated living vaccines : The pathogen is made weakened to make it nonvirulent, e.g., Oral Polio Vaccine (OPV), BCG (Bacille Calmette Guerin). MMR (Mumps, Measles, Rubella) Provide active life long immunity. (4) Antibodies as vaccines : Serum is used after a person/animal has been exposed to infection. This serum contains antibodies against that pathogen. It provides passive artificial immunity for some period only, e.g., ATS (Anti tetanus serum), more...

The diseases may be broadly classified into two types : Congenital and acquired. (1) Congenital Diseases : These are anatomical or physiological abnormalities present from birth. They may be caused by (a) a single gene mutation (alkaptonuria, phenylketonuria, albinism, sickle-cell anaemia, haemophilia, colour blindness); (b) chromosomal aberrations (Down’s syndrome, Klinefelter’s syndrome, Turner’s syndrome); or (c) environmental factors (cleft palate, harelip). Unlike the gene-and chromosome-induced congenital defects, environmentally caused abnormalities are not transmitted to the children. (2) Acquired Diseases : These diseases develop after birth. They are further of two types : communicable and non-communicable. (i) Communicable (Infectious) Diseases : These diseases are caused by viruses, rickettsias, bacteria, fungi, protozoans and worms. (ii) Noncommunicable (Noninfectious) Diseases : These diseases remain confined to the person who develops them and do not spread to others. The non-communicable diseases are of four kinds : (a) Organic or Degenerative Diseases : These diseases are due to malfunctioning of some of the important organs, e.g, heart diseases, epilepsy. Heart diseases result from the abnormal working of some part of this vital organ. Epilepsy may result from abnormal pressure on regions of the brain. (b) Deficiency Diseases : These diseases are produced by deficiency of nutrients, minerals, vitamins, and hormones, e.g., kwashiorkor, beri-beri, goitre, diabetes are just a few from a long list. (c) Allergies : These diseases are caused when the body, which has become hypersensitive to certain foreign substance, comes in contact with that substance. Hay fever is an allergic disease. (d) Cancer : This is caused by a uncontrolled growth of certain tissues in the body.

Definition : The resistance of the body to occurrence of any disease is known as immunity. Study of the ability of an organism to resist a disease is called immunology. Development of Immunity : A person may develop immunity in three ways. (1) Vaccination : It is a technique to develop immunity without infection. Weakened or dead pathogens (attenuated) or parts of pathogens are injected into a person who is required to be made immune. The pathogens given in a vaccine are unable to cause the disease but are sufficient to stimulate the formation of antibodies by the host’s immune system. Often 2 or 3 additional doses are needed to generate adequate immunity. These doses are called booster doses. (2) Antitoxins : Antibodies that neutralize toxins produced in the body or introduced from outside are, called antitoxins. Bacterial toxins are produced in the body, however antitoxins produced from outside are prepared from snake venom and is used as a remedy for snake bits. (3) Immunity through Diseases : Some diseases such as mumps, measles, small pox produce a life long immunity. Hence these diseases do not appear again. Types of Immunity : There are two main types of immunity : Inborn or innate and acquired or adaptive. (1) Inborn or Innate Immunity : This type of immunity is inherited by the organisms from their parents and protects it from birth throughout life. Examples : Human beings have inborn immunity against distemper (a fatal disease of dogs). (2) Acquired or Adaptive Immunity : This immunity is acquired in life time. The acquired immunity is of two types : Active or natural and passive or artificial. (i) Active Immunity : When an organism’s own cells produce antibodies it is called active immunity. It develops when a person suffers from a disease or gets vaccination for a disease. (ii) Passive Immunity : In passive immunity, the antibodies are produced in some other organisms (e.g. vertebrates) in response to the given antigen. These antibodies are then injected into the human body at the time of need. This is known as inoculation. For example persons infected by rabies, tetanus, Salmonella (causes food poisoning) and snake venom are given the sufficient amount of antibodies so that they can survive. Passive immunity provides immediate relief, however, active immunity requires some time for the formation of antibodies. There is another form of passive immunity. Nursing mothers transfer antibodies prepared in their body to the infants in their milk. Bottle-fed infants do not get this benefit. After a few weeks, infant’s own immunity system starts working.   Difference between Active Immunity and Passive Immunity
S.No. Active Immunity more...
Allergies : Allergy is the hypersensitiveness of a person to some foreign substance coming in contact with or entering the body. The substances that cause allergic reaction are called allergens. The common allergens are dust, pollen mould, spores, fabrics, lipsticks, nail paints, feathers, fur, plants, bacteria, foods, heat, cold, sunlight. Symptoms : The symptoms that result from an allergy may be of different kinds but mostly it affects the skin and mucous membrane. Hay fever affects the mucous membranes of the nose, eyes and upper respiratory tracts. In asthma, the lower portions of the respiratory system are severely affected. In eczema the skin becomes red, followed by the appearance of minute blisters. Eczema may affect any part of the body and is one of the most severest of all allergic symptoms. Cause : During allergic reaction there is increased release of histamine from mast cells. It causes marked dilation of all the peripheral blood vessels and the capillaries become highly permeable so that large amounts of fluid leak out from the blood into the tissues. (1) Hay fever : In this allergic form, there is swollen, reddened, running eyes and nose. The drugs called antihistamines are of major importance in the treatment of this allergic disorder. (2) Asthma : The tissue surrounding the respiratory tubes in the lungs swell up and compress the tubes. Hence there is difficulty in breathing. Antihistamine drugs are also given in this disease. (3) Anaphylactic shock : It is an allergic reaction involving all the tissues of the body and occurs in a few minutes after the injection of an antigen such as penicillin. Such a reaction is very serious. Histamine released from ruptured mast cells causes marked dilation of all the arteries so that a large amount of fluid is passed from the blood to the tissues and there is a drastic fall in blood pressure. The affected person may become unconscious and the individual may die within a short time. Autoimmunity : Sometimes it may also happen that the immune system of the body goes off the track and starts behaving against the ‘own body’ or ‘self’. This leads to a variety of diseases known as autoimmune diseases. This type of diseases depends on which type of ‘self-antigen’ is involved. When the cells acting as antigens in the same body, they are called autoantigens. The nature of autoimmune diseases depends on the autoantigens involved. For example, if the autoantigens are RBC then the body destroys its own RBC, resulting in chronic anaemia; if the autoantigens are muscle cells then it results in the destruction of its own muscles resulting in severe weakness (myasthenia gravis); if the autoantigens are liver cells, then it results in chronic hepatitis, etc. Other autoimmune diseases are insulin-dependent diabetes, Addison’s disease, ulcerative colitis and rheumatoid arthritis. Immuno deficiencies (1) Severe Combined Immuno deficiency (SCID) : Sometimes new born children are without T-cells and B-cells. These children are highly susceptible to various infections. The most serious disorder of this type more...

The disease agent is a factor (substance or force) which causes a disease by its excess or deficiency or absence. These agents are of five main types : (1) Biological Agents : These include viruses, rickettsias, bacteria, fungi, protozoans, helminthes and arthropods. The biological agents are called pathogens (Gr. Pathos = disease; genes = producing). (2) Nutrient Agents : These comprise food components such as carbohydrates, fats, proteins, minerals, vitamins and water. (3) Chemical Agents : These are further of two types (i) Endogenous Chemical Agents : These are formed in the body itself and include hormones, enzymes, urea and uric acid. (ii) Exogenous Chemical Agents : These enter the body from outside by inhalation, ingestion or inoculation. Pollutants (fumes, gases, dusts, metals) and allergens (spores, pollen) are examples. (4) Physical Agents : These include heat, cold, humidity, pressure radiation, electricity and sound. (5) Mechanical Agents : These comprise chronic friction or other mechanical forces which result in injury, sprain, dislocation fracture. (6) Deficiency and Excess of substances : e.g. Hormones, enzymes. Some diseases are caused by genetic disorders and lack or underdevelopment of organs. The agents for certain diseases such as peptic ulcers, coronary heart diseases and hypertension, are not fully known.

Immune response : Nature has provided certain ways in the body to defend ourselves from the invention of pathogens and therefore, from the disease. The ability of a host’s body to prevent or overcome the effects caused due to the invention by pathogenic organisms and its toxins is known as resistance and immunity. Resistance is considered as an inherent factor and those acquired during life to overcome the disease, while the immunity is accepted to be due to the acquired factors that help in resistance. The host body has two lines of defence that must be overcome by a pathogen before establishing an infection. External defence mechanism : This defence mechanism involves mechanical and chemical factors e.g. skin, mucous membrane, mucous secretion, peristalsis, coughing, sneezing, shedding tears, etc. Chemicals are lysozymes present in the body. Internal defence mechanism : This mechanism of defence has two lines of defence against pathogen : (1) Non-specific Defence Mechanism : It is further of two types : external defence or first line of defence and internal defence or second line of defence. (i) External Defence : It includes physical and chemical barriers. (a) Physical Barriers
  • Skin : The skin is physical barrier of body. Its outer tough layer, the stratum corneum prevents the entry of bacteria and viruses.
  • Mucous Membrane : Mucus secreted by mucous membrane traps the microorganisms and immobilises them. Microorganisms and dust particles can enter the respiratory tract with air during breathing which are trapped in the mucus. The cilia sweep the mucus loaded with microorganisms and dust particles into the pharynx (throat). From the pharynx it is thrown out or swallowed for elimination with the faeces.
(b) Chemical barriers : Oil secreted by the oil glands and sweat secreted by sweat glands make the surface of the skin acidic \[(ph\,\,3-5).\] This does not allow the microorganisms to establish on the skin. Some friendly bacteria also occur on the skin which releases acids and other metabolic wastes that check the growth of pathogens. The sweat also contains an enzyme named lysozyme that destroys the cell walls of many bacteria. The mesh of fine hair in our nostrils filters out particles which may carry pathogens. Nasal secretions also destroy the harmful foreign germs with their lysozyme. Certain bacteria normally live in vagina. These bacteria produce lactic acid. Lactic acid kills the foreign bacteria. Thus physical and chemical barriers form the first line of defence. (ii) Internal Defence : The internal defence is carried on by white blood corpuscles, macrophages, inflammatory reaction, fever and interferons. (a) White blood corpuscles (Leucocytes) : The leucocytes in general and lymphocytes in particular are capable of squeezing out through the wall of the blood capillaries into the extra-vascular regions. This phenomenon is called diapedesis. The leucocytes protect in different ways.
  • Lymphocytes : Lymphocytes can produce plasma cells which secrete antibodies to provide immunity.
  • Monocytes : They are phagocytic in action.
  • Eosinophils : Eosinophils can attach more...

Apiculture is the science of rearing honeybees for obtaining honey, wax and venom. It is a profitable money-making hobby. It forms a cottage industry, when carried out on a large scale. Three species of honey bees are commonly found in india vig. Apis indica (The small indian bee), Apis florea (The little indian bee) and Apis dorsata (the giant bee) other important species include Apis mellifera (the common European bee) and apis adamsoni (the African bee) In india the commonly domesticated species are Apis milifera and Apis Indica. Honeybee-Apis : Like termites, honeybees are social insects known for producing honey and beeswax, and for living in very highly organized colonies. These feed upon nectar and pollen of flowers, possess “sucking and chewing” mouth parts, and undergo complete metamorphosis. Social Organisation of Honey Bee A highly organised division of labour is found in the colony of honey bees. A good and well developed colony of bees had 40 to 50 thousand individuals consisting of 3 castes viz. queen, drone and worker. (1) The Queen : It is a well developed fertile female provided with immensely developed ovaries. Commonly one queen is found to be present in each hive and feeds on Royal Jelly. The queen is 15 to 20 mm in length and can be easily distinguished by her long tapering abdomen, short legs and wings. Structurally she is unable to produce wax or honey or gather pollen nector. By the combination of ovipositor-cum sting, a structure is developed which aids in egg laying. It is said that the queen gets mated only in her life but in a single chance of mating, drone releases two crore sperms which are sufficient for the fertilization of the eggs at the time of laying by the female throughout her life span. One queen lays about \[1,5002,000\] eggs in day. In the whole life span of 2-5 years a queen lays about 15,00,000 eggs. When the queen in a colony looses its eggs lying capacity, another worker of the same colony starts feeding on queen’s diet i.e., Royal Jelly and develops into a new queen and is provided with the facilities of real queen. At the same time old queen may be driven out but sometimes some workers object that as to why the mother of the colony be driven out so ultimately they also come out with the mother. Sometimes when 2 to 3 queens are developed in a colony, only one takes the position of the real queen and the others come out with some workers to establish new colonies. This phenomenon is known as swarming. (2) The Drone : The drone is the male member of the honey bee colony which fertilizes the queen so called as king of the colony. They are reared from an unfertile egg in large drone cell. Drone are totally dependent on the workers and have been seen begging for honey from the workers. The sole duty of the drone is to fertilize the virgin queen. more...

The camel is a large, horn less, ruminant mammal of genus Camelus. It is popularly called “the ship of the desert” because of its great travelling power in a desert. It is a valuable beast of burden in hot desert and semidesert regions as it can live on minimum food and water when travelling with load. Types of camels : There are two types of camels : (1) Arabian camels (Camelus dromidarius) : With a single hump, short hair and found in north Africa to India. It does not occur in wild form. (2) Turkish or bactrian camel (Camelus bactrianus) : With two humps, long hair and found in Gobi desert of central Asia. It occurs in wild form also. Feeding : Camels are fed on dry fodder (barley, straw) supplemented with chopped green fodder made of pulses, mustard and green pees. They browse on trees, shrubs and bushes. The size of the hump is a good indicator of its health. Breeding : There are four kinds of camels in India. These are Jaisalmeri, Sindhi and Bikaneri found in Rajasthan and Kutchi found in Gujrat. They have a well-defined breeding season. Camels breed in winter (November to March). Diseases : Camels suffer diseases such as anthrax,  pneumonia, camel-pox and surra.


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