"Those who drag in the use of human blood for internal remedies of diseases...sin gravely."
Thomas Bartholin, professor of anatomy, 1616-1680
James Blundell (1790-1878), an obstetrician and gynecologist at Guy's Hospital, London, realized that blood transfusions offered a possible solution for women who suffered severe hemorrhage following childbirth. Blundell was familiar with the work of John Leacock, who, in 1816, had reported experiments in cats and dogs, establishing that the donor and recipient had to be of the same species.
The first human transfusion supervised by Blundell did not in fact involve an obstetric case, but a thirty- five-year-old man with stomach cancer. On December 22,1818, the man was transfused with about fourteen ounces of blood administered by a syringe in small amounts from several human donors. Despite a slight improvement, the patient died fifty-six hours later.
To facilitate transfusions Blundell devised an apparatus, known as Blundell's Impeller, consisting of
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