Beta blockers are drugs that block the stimulating action of noradrenaline—the "fight or flight" hormone—thereby reducing the force of the heartbeat and the workload of the heart. Today they are widely used to treat angina, high blood pressure, and irregular heart rhythms, and to improve heart muscle function in cardiomyopathies.
Beta blockers were developed in 1956 by Sir James Black [b. 1924), a Scottish doctor working for ICI in the United Kingdom. Black had personal as well as professional reasons for his interest in cardiovascular disease. His father had a fatal heart attack following a car accident, making Black ponder the role of stress in producing adrenaline, angina, and heart attacks.
At the time, many of the drugs used to treat angina were vasodilators (causing dilation of the blood vessels), in particular nitrites, which increased the blood supply, and therefore the amount of oxygen to the heart. However, these caused
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