"Prozac® enjoyed [a] career of renown... rumors... scandal... and finally a quiet rehabilitation."
Peter D. Kramer, Listening to Prozac (1993)
Prozac® is the registered trademarked name for fluoxetine hydrochloride, the world's most widely prescribed antidepressant. It was the first in a new class of drugs for depression called selective serotonin re-uptake inhibitors (SSRIs), which work by increasing brain levels of serotonin, the neurotransmitter thought to influence sleep, appetite, aggression, and mood. Prozac® works by inhibiting re-uptake of the neurotransmitter (where it-is either destroyed or retrieved into the cell), thereby amplifying its levels.
At Eli Lilly and Company, the team of inventors behind Prozac® included Bryan Molloy Ray Fuller, and David Wong. In the early 1980s it was known that the antihistamine diphenhydramine showed some antidepressant-like properties. As a starting point, the team took 3-phenoxy-3-phenylpropylamine (which is a compound structurally similar to diphenhydramine) and synthesized dozens of its derivatives. Fluoxetine hydrochloride
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